HPV L1 detection discriminates cervical precancer from transient HPV infection: a prospective international multicenter study
| Autor: | Matthias W. Beckmann, Christine Mian, Ralf Hilfrich, Birgit Simm, Martin Koch, Heinz Sander, Giovanni Negri, Ellen C. Obermann, Gieri Cathomas, Lukas Bubendorf, Zsuzsanna Bánrévi, Grit Mehlhorn, Markus Lütge, Henrik Griesser, Anke Weiss |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Mild Dysplasia
Adult Pathology medicine.medical_specialty Adolescent Remission Spontaneous Uterine Cervical Neoplasms Spontaneous remission Cervical intraepithelial neoplasia Pathology and Forensic Medicine Young Adult Uterine Cervical Dysplasia medicine Humans Moderate Dysplasia Aged Colposcopy Aged 80 and over medicine.diagnostic_test business.industry Papillomavirus Infections HPV infection virus diseases Oncogene Proteins Viral Middle Aged medicine.disease Immunohistochemistry female genital diseases and pregnancy complications Cytopathology Capsid Proteins Female business Papanicolaou Test |
| Zdroj: | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 26(7) |
| ISSN: | 1530-0285 |
| Popis: | The benefits of cytology-based cervical cancer screening programs in reducing morbidity and mortality are well recognized. Especially, overtreatment of human papillomavirus (HPV) high-risk positive early dysplastic lesions may have a negative impact on reproductive outcomes for fertile women. To optimize the clinical management an objective standard is needed to distinguish precancer that requires treatment, from spontaneously resolving HPV infections. In the current study, we examined the prognostic relevance of HPV-L1 capsid protein analysis with Cytoactiv in an international prospective multicenter study including 908 HPV high-risk positive early dysplastic lesions (LSIL/HSIL) during a follow-up period of 54 months. The clinical end points of the study were histologically confirmed CIN3+ as progression, CIN1/2 for stable disease and repeated negative Pap smears as spontaneous clinical remission. The difference of the clinical outcome of HPV-L1-negative and HPV-L1-positive cases was statistically highly significant (P-value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|