Differential expression of the metastasis suppressor KAI1 in decidual cells and trophoblast giant cells at the feto-maternal interface
| Autor: | Yamashita Tadashi, Tae Bon Koo, Min-Su Han, Won Joon Seong, Je-Yong Choi |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Trophoblast giant cells Placenta Biology Endometrium Kangai-1 Protein Biochemistry Giant Cells lcsh:Biochemistry Andrology Mice KAI1 medicine Decidua Animals lcsh:QD415-436 Decidual cells Metastasis suppressor lcsh:QH301-705.5 Molecular Biology reproductive and urinary physiology Cells Cultured Research Articles Reverse Transcriptase Polymerase Chain Reaction Trophoblast Placentation General Medicine Immunohistochemistry female genital diseases and pregnancy complications Trophoblasts Mice Inbred C57BL medicine.anatomical_structure lcsh:Biology (General) Giant cell Immunology embryonic structures Female |
| Zdroj: | BMB Reports BMB Reports, Vol 46, Iss 10, Pp 507-512 (2013) BMB REPORTS(46): 10 |
| ISSN: | 1976-670X |
| Popis: | Invasion of trophoblasts into maternal uterine tissue is essential for establishing mature feto-maternal circulation. The trophoblast invasion associated with placentation is similar to tumor invasion. In this study, we investigated the role of KAI1, an anti-metastasis factor, at the maternal-fetal interface during placentation. Mouse embryos were obtained from gestational days 5.5 (E5.5) to E13.5. Immunohistochemical analysis revealed that KAI1 was expressed on decidual cells around the track made when a fertilized ovum invaded the endometrium, at days E5.5 and E7.5, and on trophoblast giant cells, along the central maternal artery of the placenta at E9.5. KAI1 in trophoblast giant cells was increased at E11.5, and then decreased at E13.5. Furthermore, KAI1 was upregulated during the forskolinmediated trophoblastic differentiation of BeWo cells. Collectively, these results indicate that KAI1 is differentially expressed in decidual cells and trophoblasts at the maternal-fetal interface, suggesting that KAI1 prevents trophoblast invasion during placentation. [BMB Reports 2013; 46(10): 507-512] |
| Databáze: | OpenAIRE |
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