Interactions of oxytocin and vasopressin with CRF on the rat colon
| Autor: | Cynthia L. Williams, M.H Shannon, T. F. Burks, C.C. Bihm, W.J Short |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
endocrine system
medicine.medical_specialty Vasopressin Colon Corticotropin-Releasing Hormone Vasopressins Neuropeptide Endogeny Biology Oxytocin Rats Sprague-Dawley Cellular and Molecular Neuroscience Endocrinology Mediator Internal medicine medicine Animals Vasoconstrictor Agents Drug Interactions Injections Intraventricular Gastrointestinal tract Dose-Response Relationship Drug urogenital system Endocrine and Autonomic Systems General Medicine Peripheral Rats Neurology Female hormones hormone substitutes and hormone antagonists Injections Intraperitoneal medicine.drug |
| Zdroj: | Neuropeptides. 31(1) |
| ISSN: | 0143-4179 |
| Popis: | Corticotropin-releasing factor (CRF), a primary mediator of stress responses, produces changes in the gastrointestinal tract identical to those induced by stress. CRF is tenfold more potent in females than in males, but gonadectomy reverses this difference. We postulated that positive modulators of CRF, such as oxytocin (OT) and vasopressin (AVP), may act in females to potentiate effects of CRF and thus could account for the gender-related differences in colonic sensitivity to CRF and stress. Given with CRF, neither OT, peripheral AVP, nor central AVP increased colonic transit any more than CRF alone, suggesting that OT and AVP do not potentiate CRF's actions in the colon. These data indicate that endogenous OT and AVP do not directly affect colonic transit, and that OT and AVP do not account for the gender-related differences in the effects of stress and CRF on colonic transit. |
| Databáze: | OpenAIRE |
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