Complementary regional heterogeneity information from COPD patients obtained using oxygen-enhanced MRI and chest CT

Autor:	Kazuya Tanimura, Hiroshi Kusahara, Shigeo Muro, Susumu Sato, Koji Fujimoto, Yasutaka Fushimi, Atsuyasu Sato, Takeshi Kubo, Yoshiharu Ohno, Toyohiro Hirai, Naotaka Sakashita, Naoya Tanabe, Koichi Hasegawa, Yoshinori Fuseya, Michiaki Mishima, Kaori Togashi, Aki Kido, Kiyoshi Uemasu
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Adult medicine.medical_specialty lcsh:Medicine 030218 nuclear medicine & medical imaging Pulmonary function testing 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine DLCO Internal medicine medicine Humans lcsh:Science Lung Aged COPD Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Magnetic resonance imaging respiratory system medicine.disease Magnetic Resonance Imaging Respiratory Function Tests respiratory tract diseases Oxygen medicine.anatomical_structure 030228 respiratory system Cardiology Breathing Arterial blood lcsh:Q business Tomography X-Ray Computed Perfusion
Zdroj:	PLoS ONE, Vol 13, Iss 8, p e0203273 (2018)
ISSN:	1932-6203
Popis:	Background The heterogeneous distribution of emphysema is a key feature of chronic obstructive pulmonary disease (COPD) patients that typically is evaluated using high-resolution chest computed tomography (HRCT). Oxygen-enhanced pulmonary magnetic resonance imaging (OEMRI) is a new method to obtain information regarding regional ventilation, diffusion, and perfusion in the lung without radiation exposure. We aimed to compare OEMRI with HRCT for the assessment of heterogeneity in COPD patients. Methods Forty patients with stable COPD underwent quantitative HRCT, OEMRI, and pulmonary function tests, including arterial blood gas analysis. OEMRI was also performed on nine healthy control subjects. We measured the severity of emphysema (percent low attenuation volume; LAV%) in whole lungs and the standard deviations (SDs) of the LAV% values of 10 isovolumetric partitions (SD-LAV) as an index of cranial-caudal heterogeneity. Similarly, relative enhancement ratios of oxygen (RERs) in whole lungs from OEMRI and SD-RER were analyzed. Results COPD patients showed a lower mean RER than control subjects (12.6% vs 22.0%, p
Databáze:	OpenAIRE
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