Screening of preservatives by HPLC-PDA-ESI/MS: A focus on both allowed and recently forbidden compounds in the new EU cosmetics regulation
| Autor: | Luca Regazzoni, Giampaolo Incarnato, Carlo Mustazza, Raffaele Lecce, Alessia Panusa, R. Porrà |
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| Rok vydání: | 2015 |
| Předmět: |
Preservative
Spectrometry Mass Electrospray Ionization Formic acid media_common.quotation_subject Clinical Biochemistry Pharmaceutical Science Cosmetics 01 natural sciences Analytical Chemistry chemistry.chemical_compound Drug Discovery media_common.cataloged_instance European Union European union Acetonitrile Spectroscopy Chromatography High Pressure Liquid media_common Benzoic acid Chromatography 010405 organic chemistry 010401 analytical chemistry 0104 chemical sciences chemistry Propylparaben Isopropyl |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 125 |
| ISSN: | 1873-264X |
| Popis: | Commission regulation (EU) No 358/2014 amending the new regulation (EC) No 1223/2009 on cosmetics has prohibited the use of isopropyl-, isobutyl-, phenyl-, benzyl- and pentylparaben. Furthermore, Commission regulation (EU) No 1004/2014 has lowered the maximum permitted concentration of butyl- and propylparaben in cosmetics and it has also banned them in leave-on products designed for application on the nappy area of children under three years of age. A HPLC-PDA-ESI/MS method has been developed herein for the detection of seventeen preservatives, both the most utilised and the recently forbidden by the new EU regulations. The separation of these compounds, including benzoic acid and its derivatives in a 1.10 - 3.04 log Pow range, has been performed with a gradient elution on a Symmetry(®) C18 column (250×4.6mm i.d., particle size 5μm) with water and acetonitrile (0.1% formic acid) as mobile phase. Quantification has been carried out by HPLC-PDA. The method has been validated and successfully applied to the analysis of a large number of cosmetics with different functions like rinse-off and leave-on, or composition like skin, hair, face and oral products. |
| Databáze: | OpenAIRE |
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