Near-Infrared Fluorescent Probes for the Detection of Cancer-Associated Proteases
| Autor: | Jamie I. Scott, Marc Vendrell, Qinyi Deng |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Proteases
medicine.medical_treatment Reviews Early detection Computational biology 010402 general chemistry 01 natural sciences Biochemistry 03 medical and health sciences Optical imaging Neoplasms Biomarkers Tumor medicine Animals Humans Personalized therapy Fluorescent Dyes 030304 developmental biology chemistry.chemical_classification 0303 health sciences Protease Cancer General Medicine medicine.disease Fluorescence Molecular Imaging 0104 chemical sciences 3. Good health Enzyme Microscopy Fluorescence chemistry Molecular Medicine Peptide Hydrolases |
| Zdroj: | Scott, J, Deng, Q & Vendrell, M 2021, ' Near-infrared fluorescent probes for the detection of cancer-associated proteases ', Acs chemical biology . https://doi.org/10.1021/acschembio.1c00223 ACS Chemical Biology |
| ISSN: | 1554-8937 1554-8929 |
| DOI: | 10.1021/acschembio.1c00223 |
| Popis: | Proteases are enzymes capable of catalysing protein breakdown, which is critical across many biological processes. There are several families of proteases, each of which perform key functions through the degradation of specific proteins. As our understanding of cancer improves, it has been demonstrated that several proteases can be overactivated during the progression of cancer and contribute to malignancy. Optical imaging systems that employ near-infrared (NIR) fluorescent probes to detect protease activity offer clinical promise, both for early detection of cancer as well as for the assessment of personalised therapy. In this article, we review the design of NIR probes and their successful application for the detection of different cancer-associated proteases. |
| Databáze: | OpenAIRE |
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