Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol
| Autor: | Rana S Hinman, Inga Krauss, R. Taylor, Christopher J. McCarthy, Mariëtte de Rooij, Stephen P. Messier, Kristin Baker, Thomas Cochrane, Danielle L. Burke, Daniël Bossen, Kim L Bennell, Carol Ingram, Amardeep Legha, Carolien H Teirlinck, Helen P. French, Nadine E. Foster, Richard D Riley, Jesper Knoop, Robin Christensen, Melanie A. Holden, Marienke van Middelkoop, J. Haxby Abbott, Michael Doherty, Laura A. Talbot, Daniëlle A W M van der Windt, Marijke Hopman-Rock, Kanda Chaipinyo, Michael Hurley, Donald L. Patrick, Sheila Hickson, Jos Runhaar, Amy L. Evans, Krysia Dziedzic, Nilay Sahin, Christine Walker, Jenny Brown, Lucie Brosseau |
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| Přispěvatelé: | Division 6, Public and occupational health, APH - Mental Health, Kenniscentrum ACHIEVE, Faculteit Gezondheid, General Practice |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Research design
Osteoarthritis Musculoskeletal disorders Osteoarthritis Hip 0302 clinical medicine Life CH - Child Health Protocol 030212 general & internal medicine Pain Measurement Randomized Controlled Trials as Topic General Medicine Osteoarthritis Knee Random effects model Low back pain Exercise Therapy 3. Good health Hip/rehabilitation Health Research Design Meta-analysis medicine.symptom Healthy Living medicine.medical_specialty Knee/rehabilitation Pain Osteoarthritis Knee/rehabilitation Pain/etiology Osteoarthritis Hip/rehabilitation 03 medical and health sciences Rheumatology RC925 medicine Hip osteoarthritis Humans Pain Management Knee Exercise 030203 arthritis & rheumatology Protocol (science) Hip business.industry Individual participant data medicine.disease R1 Exercise Therapy/methods Physical therapy ELSS - Earth Life and Social Sciences Healthy for Life business RA Systematic Reviews as Topic |
| Zdroj: | OA Trial Bank 2017, ' Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA) : a systematic review update and individual participant data meta-analysis protocol ', BMJ Open, vol. 7, no. 12, e018971, pp. e018971 . https://doi.org/10.1136/bmjopen-2017-018971 BMJ Open, 7(12). BMJ Publishing Group BMC Open, 12, 7, e18971 BMJ Open Sport & Exercise Medicine. BMJ Publishing Group BMJ Open, 7(12):e018971. BMJ Publishing Group BMJ Open, 7, e018971 Holden, M A, Burke, D L, Runhaar, J, van Der Windt, D, Riley, R D, Dziedzic, K, Legha, A, Evans, A L, Abbott, J H, Baker, K, Brown, J, Bennell, K L, Bossen, D, Brosseau, L, Chaipinyo, K, Christensen, R, Cochrane, T, de Rooij, M, Doherty, M, French, H P, Hickson, S, Hinman, R S, Hopman-Rock, M, Hurley, M V, Ingram, C, Knoop, J, Krauss, I, McCarthy, C, Messier, S P, Patrick, D L, Sahin, N, Talbot, L A, Taylor, R, Teirlinck, C H, van Middelkoop, M, Walker, C, Foster, N E & OA Trial Bank 2017, ' Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA) : a systematic review update and individual participant data meta-analysis protocol ', BMJ Open, vol. 7, no. 12, pp. e018971 . https://doi.org/10.1136/bmjopen-2017-018971 BMJ Open |
| ISSN: | 2044-6055 2055-7647 |
| DOI: | 10.1136/bmjopen-2017-018971 |
| Popis: | IntroductionKnee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physical function are small to moderate. This may be due to insufficient targeting of exercise to subgroups of people who are most likely to respond and/or suboptimal content of exercise programmes. This study aims to identify: (1) subgroups of people with knee and hip OA that do/do not respond to therapeutic exercise and to different types of exercise and (2) mediators of the effect of therapeutic exercise for reducing pain and improving physical function. This will enable optimal targeting and refining the content of future exercise interventions.Methodsand analysisSystematic review and individual participant data meta-analyses. A previous comprehensive systematic review will be updated to identify randomised controlled trials that compare the effects of therapeutic exercise for people with knee and hip OA on pain and physical function to a non-exercise control. Lead authors of eligible trials will be invited to share individual participant data. Trial-level and participant-level characteristics (for baseline variables and outcomes) of included studies will be summarised. Meta-analyses will use a two-stage approach, where effect estimates are obtained for each trial and then synthesised using a random effects model (to account for heterogeneity). All analyses will be on an intention-to-treat principle and all summary meta-analysis estimates will be reported as standardised mean differences with 95% CI.Ethics and disseminationResearch ethical or governance approval is exempt as no new data are being collected and no identifiable participant information will be shared. Findings will be disseminated via national and international conferences, publication in peer-reviewed journals and summaries posted on websites accessed by the public and clinicians.PROSPERO registration numberCRD42017054049. |
| Databáze: | OpenAIRE |
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