Comparative efficacy of antimicrobials for treatment of clinical mastitis in lactating dairy cattle: a systematic review and network meta-analysis
| Autor: | Jan M. Sargeant, M. A. Godkin, Dapeng Hu, Katheryn Churchill, David F. Kelton, Annette M. O'Connor, Charlotte B. Winder, Chong Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Network geometry Disease exposure 040301 veterinary sciences Network Meta-Analysis Placebo 0403 veterinary science 03 medical and health sciences Species group medicine Animals Lactation Intensive care medicine Mastitis Bovine Lactating dairy cattle 0303 health sciences 030306 microbiology business.industry 04 agricultural and veterinary sciences Antimicrobial medicine.disease Anti-Bacterial Agents Mastitis Meta-analysis Cattle Female Animal Science and Zoology business |
| Zdroj: | Animal Health Research Reviews. 20:229-246 |
| ISSN: | 1475-2654 1466-2523 |
| DOI: | 10.1017/s1466252319000318 |
| Popis: | A systematic review and network meta-analysis were conducted to assess the relative efficacy of antimicrobial therapy for clinical mastitis in lactating dairy cattle. Controlled trials in lactating dairy cattle with natural disease exposure were eligible if they compared an antimicrobial treatment to a non-treated control, placebo, or a different antimicrobial, for the treatment of clinical mastitis, and assessed clinical or bacteriologic cure. Potential for bias was assessed using a modified Cochrane Risk of Bias 2.0 tool. From 14775 initially identified records, 54 trials were assessed as eligible. Networks were established for bacteriologic cure by bacterial species group, and clinical cure. Disparate networks among bacteriologic cures precluded meta-analysis. Network meta-analysis was conducted for trials assessing clinical cure, but lack of precision of point estimates resulted in wide credibility intervals for all treatments, with no definitive conclusions regarding relative efficacy. Consideration of network geometry can inform future research to increase the utility of current and previous work. Replication of intervention arms and consideration of connection to existing networks would improve the future ability to determine relative efficacy. Challenges in the evaluation of bias in primary research stemmed from a lack of reporting. Consideration of reporting guidelines would also improve the utility of future research. |
| Databáze: | OpenAIRE |
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