Blasticidin A as an Inhibitor of Aflatoxin Production by Aspergillus parasiticus
| Autor: | Makoto Ono, Takefumi Nakamura, Hiroyuki Ikeda, Ryu Kawachi, Shohei Sakuda, Yasuhito Inagaki, Akira Isogai, Hiromichi Nagasawa, Jiro Nakayama, Akinori Suzuki |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pharmacology
Aflatoxin Molecular Structure biology Chemistry Stereochemistry Toxin Spectrum Analysis Biological activity Fungi imperfecti biology.organism_classification medicine.disease_cause Pyrrolidinones Aspergillus parasiticus Anti-Bacterial Agents Aspergillus Aflatoxins Drug Discovery medicine Anticarcinogen Chemical decomposition Carcinogen |
| Zdroj: | The Journal of Antibiotics. 53:1265-1271 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.53.1265 |
| Popis: | Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 microM. |
| Databáze: | OpenAIRE |
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