MicroRNA-105 inhibits human glioma cell malignancy by directly targeting SUZ12
| Autor: | Yingyi Wang, Xiaoming Lu, Yongping You, Shuo Xu, Weining Wu, Yuanyuan Jiao, Jie Zhang, Jian Zhang, Jiale Zhang, Ailin Lu, Junxia Zhang, Qun Yu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Human glioma Cell Apoptosis Malignancy 03 medical and health sciences Mice 0302 clinical medicine Cell Movement Glioma Cell Line Tumor microRNA medicine SUZ12 Biomarkers Tumor Animals Humans Neoplasm Invasiveness neoplasms RC254-282 Cell Proliferation Neoplasm Staging business.industry Polycomb Repressive Complex 2 Neoplasms. Tumors. Oncology. Including cancer and carcinogens General Medicine medicine.disease Xenograft Model Antitumor Assays nervous system diseases Neoplasm Proteins Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Primary Malignant Brain Tumors Cancer research Female Malignant progression business Transcription Factors |
| Zdroj: | Tumor Biology, Vol 39 (2017) |
| ISSN: | 1423-0380 |
| Popis: | Glioma accounts for the majority of primary malignant brain tumors in adults and is highly aggressive. Although various therapeutic approaches have been applied, outcomes of glioma treatment remain poor. MicroRNAs are a class of small noncoding RNAs that function as regulators of gene expression. Accumulating evidence shows that microRNAs are associated with tumorigenesis and tumor progression. In this study, we found that miR-105 is significantly downregulated in glioma tissues and glioma cell lines. We identified suppressor of Zeste 12 homolog as a novel direct target of miR-105 and showed that suppressor of Zeste 12 homolog protein levels were inversely correlated with the levels of miR-105 expression in clinical specimens. Overexpression of miR-105 inhibited cell proliferation, tumorigenesis, migration, invasion, and drug sensitivity, whereas overexpression of suppressor of Zeste 12 homolog antagonized the tumor-suppressive functions of miR-105. Taken together, our results indicate that miR-105 plays a significant role in tumor behavior and malignant progression, which may provide a novel therapeutic strategy for the treatment of glioma and other cancers. |
| Databáze: | OpenAIRE |
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