Dihydroquinolines as novel n-NOS inhibitors
| Autor: | Fiona M. McDonald, Detlev Suelzle, Stefan Jaroch, Gerardine Burton, Hartmut Rehwinkel, Peter Hoelscher, Margrit Hillmann |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Stereochemistry
Clinical Biochemistry Pharmaceutical Science Nitric Oxide Synthase Type I Ring (chemistry) Biochemistry Chemical synthesis Amidine chemistry.chemical_compound Drug Discovery Enzyme Inhibitors Benzene Molecular Biology chemistry.chemical_classification biology Organic Chemistry General Medicine In vitro Enzyme chemistry Enzyme inhibitor biology.protein Quinolines Molecular Medicine Nitric Oxide Synthase Selectivity |
| Zdroj: | Bioorganicmedicinal chemistry letters. 12(18) |
| ISSN: | 0960-894X |
| Popis: | Dihydroquinolines have been synthesized and have been shown to be potent n-NOS inhibitors. Selectivity versus e-NOS was increased to approximately 100-fold through appropriate substitution at the benzene ring. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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