Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis
| Autor: | Gudrun Reynisdottir, Ytterberg Aj, Lars Klareskog, Anca I. Catrina, Malmström |
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| Rok vydání: | 2014 |
| Předmět: |
Peptides
Cyclic Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Immune system Rheumatology Immunity medicine Humans Lung Autoantibodies 030304 developmental biology Inflammation 030203 arthritis & rheumatology 0303 health sciences business.industry Smoking Autoantibody medicine.disease 3. Good health Rheumatoid arthritis Immunology Irritants Citrulline Joints business |
| Zdroj: | Nature Reviews Rheumatology |
| ISSN: | 1759-4804 1759-4790 |
| DOI: | 10.1038/nrrheum.2014.115 |
| Popis: | Rheumatoid arthritis (RA) is a prototype for a criterion-defined inflammatory disease, for which the aetiology and initial molecular pathogenesis has been elusive for a long time. We describe in this Review how studies on the interplay between specific immunity, alongside genetic and environmental predisposing factors, provide new tools to understand the molecular basis of distinct subsets of the disease. A particular emphasis is on the possibility that pathogenic immune reactions might be initiated at other sites than the joints, and that the lungs could harbour such sites. New data strengthen this concept, showing that local immunity towards citrullinated proteins and accompanying inflammation might be present in the lungs early during disease development. This progress makes RA an interesting case for the future development of therapies that might be directed against disease-inducing immunity even before inflammation and destruction of joints has begun. |
| Databáze: | OpenAIRE |
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