Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist
| Autor: | Fawzia M Refaie, Shugo Suzuki, Hala M. Ghanem, Makoto Asamoto, Kumiko Ogawa, Mingxi Tang, Amr Y. Esmat, Tomoyuki Shirai, Naomi Hokaiwado, Mahmoud M. Said |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Agonist Cancer Research medicine.medical_specialty Antineoplastic Agents Hormonal medicine.drug_class Antigens Polyomavirus Transforming Transgene Adenocarcinoma Biology Androgen-Binding Protein Animals Genetically Modified Gonadotropin-Releasing Hormone Prostate cancer Leuprorelin Prostate Internal medicine medicine Animals Testosterone RNA Messenger Oligonucleotide Array Sequence Analysis DNA synthesis Reverse Transcriptase Polymerase Chain Reaction Microarray analysis techniques Prostatic Neoplasms Seminal Vesicles General Medicine Luteinizing Hormone medicine.disease Immunohistochemistry Rats Endocrinology medicine.anatomical_structure Oncology Receptors Androgen Follicle Stimulating Hormone Leuprolide medicine.drug Hormone |
| Zdroj: | Cancer Science. 97:459-467 |
| ISSN: | 1349-7006 1347-9032 |
| Popis: | The effects of leuprorelin acetate, a luteinizing hormone-releasing hormone agonist (LHRH-A), on prostate carcinogenesis in probasin/SV40 Tag transgenic rat was investigated. Fifteen weeks after administration of 0.28 and 2.8 mg/kg leuprorelin, prostate weights and serum testosterone levels were significantly decreased compared to values for transgenic controls. Histopathological findings revealed that the incidence of prostatic adenocarcinomas was significantly reduced in ventral, dorsal and lateral lobes of the prostate, correlating with decreased expression of SV40 Tag oncoprotein as well as inhibition of DNA synthesis and proliferation of epithelial cells in neoplastic lesions of the ventral prostate. Microarray analysis further showed leuprorelin acetate to significantly inhibit testicular steroidogenesis, suppressing the expression of SV40 Tag oncoprotein and altering the expression of a large number of genes which might be involved in the inhibition of prostate cancer progression in this rat model. |
| Databáze: | OpenAIRE |
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