The Cancer Stem Cell Concept in Multiple Myeloma – From Phenomenology to Characterisation
| Autor: | Steen Møller Hansen, Kirsten Fogd, Louise Hvilshøj Madsen, Hans Erik Johnsen, Malene Krag Kjeldsen |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Fogd, K, Hansen, S M, Madsen, L H, Kjeldsen, M K & Johnsen, H E 2010, ' The Cancer Stem Cell Concept in Multiple Myeloma-From Phenomenology to Characterisation ', European Haematology, vol. 4, pp. 94-96 . Aalborg University |
| ISSN: | 2045-5275 |
| DOI: | 10.17925/eoh.2010.04.0.94 |
| Popis: | Although there have been great developments in the treatment regimes offered to patients with multiple myeloma (MM), it is still an incurable disease. An emerging idea in MM research is the concept of the cancer stem cell, which has been identified in other cancer types in an attempt to explain incurability. The cancer stem cell is defined in the same manner as regular tissue stem cells. They are thought to be infrequent among the tumour cells, quiescent and able to maintain their population by self-renewal. Although ‘the cancer stem cell’ has not yet been identified, substantial evidence has been gathered over the past few years suggesting that a tumour-initiating cell population may be present in MM. Further characterisation of B-lineage subsets in bone marrow and blood, including memory B cells and plasmablasts, is necessary to support the concept that the cancer stem cell is one of the central players in the pathogenesis of this disease. |
| Databáze: | OpenAIRE |
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