Polycystic kidney disease: an unrecognized emerging infectious disease?

3)-beta-D-glucans in cyst fluids from human kidneys with PKD. Fatty acid analysis of cyst fluid confirmed the presence of 3-hydroxy fatty acids characteristic of endotoxin. Tissue and cyst fluid from three PKD patients were examined for fungal components. Serologic tests showed Fusarium, Aspergillus, and Candida antigens. IgE, but not IgG, reactive with Fusarium and Candida were also detected in cyst fluid. Fungal DNA was detected in kidney tissue and cyst fluid from these three PKD patients, but not in healthy human kidney tissue. We examine the intertwined nature of the actions of endotoxin and fungal components, sphingolipid biology in PKD, the structure of PKD gene products, infections, and integrity of gut function to establish a mechanistic hypothesis for microbial provocation of human cystic disease. Proof of this hypothesis will require identification of the microbes and microbial components involved and multifaceted studies of PKD cell biology. -->

ISSN:	1080-6040
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb56f767d281a889f73caa4abd973b1 https://pubmed.ncbi.nlm.nih.gov/9204292
Rights:	OPEN
Přírůstkové číslo:	edsair.doi.dedup.....ffb56f767d281a889f73caa4abd973b1
Autor:	M A Dombrink-Kurtzman, Deborah M. Nowak, Marcia A. Miller-Hjelle, W R Mayberry, F S Darras, J T Hjelle, M Jones, S W Peterson
Rok vydání:	1997
Předmět:	beta-Glucans lcsh:Medicine Biology Immunoglobulin E Communicable Diseases Microbiology lcsh:Infectious and parasitic diseases Antigen medicine Polycystic kidney disease Humans Cyst lcsh:RC109-216 DNA Fungal Glucans Kidney Polycystic Kidney Diseases Sphingolipids lcsh:R Fatty Acids medicine.disease musculoskeletal system Sphingolipid United States Endotoxins medicine.anatomical_structure Limulus amebocyte lysate Immunology biology.protein Emerging infectious disease cardiovascular system Research Article
Zdroj:	Emerging Infectious Diseases Emerging Infectious Diseases, Vol 3, Iss 2, Pp 113-127 (1997)
ISSN:	1080-6040
Popis:	Polycystic kidney disease (PKD) is one of the most common genetic diseases in humans. We contend that it may be an emerging infectious disease and/or microbial toxicosis in a vulnerable human subpopulation. Use of a differential activation protocol for the Limulus amebocyte lysate (LAL) assay showed bacterial endotoxin and fungal (1-->3)-beta-D-glucans in cyst fluids from human kidneys with PKD. Fatty acid analysis of cyst fluid confirmed the presence of 3-hydroxy fatty acids characteristic of endotoxin. Tissue and cyst fluid from three PKD patients were examined for fungal components. Serologic tests showed Fusarium, Aspergillus, and Candida antigens. IgE, but not IgG, reactive with Fusarium and Candida were also detected in cyst fluid. Fungal DNA was detected in kidney tissue and cyst fluid from these three PKD patients, but not in healthy human kidney tissue. We examine the intertwined nature of the actions of endotoxin and fungal components, sphingolipid biology in PKD, the structure of PKD gene products, infections, and integrity of gut function to establish a mechanistic hypothesis for microbial provocation of human cystic disease. Proof of this hypothesis will require identification of the microbes and microbial components involved and multifaceted studies of PKD cell biology.
Databáze:	OpenAIRE
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