Hybrid cavity-coupled plasmonic biosensors for low concentration, label-free and selective biomolecular detection
| Autor: | Wade Wilson, Abraham Vázquez-Guardado, J. Manuel Perez, Debashis Chanda, Jeanette K. Ortega, Alexandra Smith |
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| Rok vydání: | 2016 |
| Předmět: |
Streptavidin
Analyte Optics and Photonics Materials science Surface Properties Nanotechnology 02 engineering and technology Biosensing Techniques 010402 general chemistry 01 natural sciences law.invention Atomic layer deposition chemistry.chemical_compound law Limit of Detection Aluminum Oxide Plasmon Detection limit 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics 0104 chemical sciences Nanostructures chemistry Hybrid system Optical cavity 0210 nano-technology Biosensor |
| Zdroj: | Optics express. 24(22) |
| ISSN: | 1094-4087 |
| Popis: | Simple optical techniques that can accurately and selectively identify organic and inorganic material in a reproducible manner are of paramount importance in biological sensing applications. In this work, we demonstrate that a nanoimprinted plasmonic pattern with locked-in dimensions supports sharp deterministic hybrid resonances when coupled with an optical cavity suitable for high sensitive surface detection. The surface sensing property of this hybrid system is quantified by precise atomic layer growth of aluminum oxide using the atomic layer deposition technique. The analyte specific sensing ability is demonstrated in the detection of two dissimilar analytes, inorganic amine-coated iron oxide nanoparticles and organic streptavidin protein. Femto to nanomolar detection limits were achieved with the proposed coupled plasmonic system based on the versatile and robust soft nanoimprinting technique, which promises practical low cost biosensors. |
| Databáze: | OpenAIRE |
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