Urinary Excretion of N1-methyl-2-pyridone-5-carboxamide and N1-methylnicotinamide in Renal Transplant Recipients and Donors

Autor: Karin J Borgonjen-van den Berg, Carolien P J Deen, Anna van der Veen, Johanna M. Geleijnse, António W Gomes-Neto, M. Rebecca Heiner-Fokkema, Ido P. Kema, Stephan J. L. Bakker
Přispěvatelé: Center for Liver, Digestive and Metabolic Diseases (CLDM), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Lifestyle Medicine (LM), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
CLEARANCE
Nutrition and Disease
NIACIN STATUS
lcsh:Medicine
Urine
GLOMERULAR-FILTRATION-RATE
Diagnostics & Crisis Organization
0302 clinical medicine
Voeding en Ziekte
kidney function
ALDEHYDE OXIDASE
N1-methyl-2-pyridone-5-carboxamide
0303 health sciences
Kidney
education.field_of_study
Diagnostiek & Crisisorganisatie
PLASMA
Tryptophan
NICOTINAMIDE
General Medicine
renal transplantation
medicine.anatomical_structure
vitamin B-3
biomarker
vitamin B3
Niacin
medicine.medical_specialty
Urinary system
Population
Urology
N-1-methylnicotinamide
Renal function
030209 endocrinology & metabolism
urinary excretion
OS&DAEB
METABOLISM
Article
N1-methylnicotinamide
Excretion
03 medical and health sciences
Kidney function
Urinary excretion
Diabetes mellitus
medicine
tryptophan
YOUNG MEN
education
BIOCHEMICAL MARKERS
VLAG
030304 developmental biology
N-1-methyl-2-pyridone-5-carboxamide
business.industry
lcsh:R
N-METHYL-2-PYRIDONE-5-CARBOXAMIDE
Renal transplantation
Biomarker
medicine.disease
Vitamin B3
Niacin status
business
Zdroj: Journal of Clinical Medicine, 9(2)
Journal of Clinical Medicine
Volume 9
Issue 2
Journal of Clinical Medicine, Vol 9, Iss 2, p 437 (2020)
Journal of Clinical Medicine, 9(2). MDPI AG
Journal of Clinical Medicine 9 (2020) 2
ISSN: 2077-0383
DOI: 10.3390/jcm9020437
Popis: N1-methylnicotinamide (N1-MN) and N1-methyl-2-pyridone-5-carboxamide (2Py) are successive end products of NAD+ catabolism. N1-MN excretion in 24-h urine is the established biomarker of niacin nutritional status, and recently shown to be reduced in renal transplant recipients (RTR). However, it is unclear whether 2Py excretion is increased in this population, and, if so, whether a shift in excretion of N1-MN to 2Py can be attributed to kidney function. Hence, we assessed the 24-h urinary excretion of 2Py and N1-MN in RTR and kidney donors before and after kidney donation, and investigated associations of the urinary ratio of 2Py to N1-MN (2Py/N1-MN) with kidney function, and independent determinants of urinary 2Py/N1-MN in RTR. The urinary excretion of 2Py and N1-MN was measured in a cross-sectional cohort of 660 RTR and 275 healthy kidney donors with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Linear regression analyses were used to investigate associations and determinants of urinary 2Py/N1-MN. Median 2Py excretion was 178.1 (130.3&ndash
242.8) &mu
mol/day in RTR, compared to 155.6 (119.6&ndash
217.6) &mu
mol/day in kidney donors (p <
0.001). In kidney donors, urinary 2Py/N1-MN increased significantly after kidney donation (4.0 ±
1.4 to 5.2 ±
1.5, respectively
p <
0.001). Smoking, alcohol consumption, diabetes, high-density lipoprotein (HDL), high-sensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) were identified as independent determinants of urinary 2Py/N1-MN in RTR. In conclusion, the 24-h urinary excretion of 2Py is higher in RTR than in kidney donors, and urinary 2Py/N1-MN increases after kidney donation. As our data furthermore reveal strong associations of urinary 2Py/N1-MN with kidney function, interpretation of both N1-MN and 2Py excretion may be recommended for assessment of niacin nutritional status in conditions of impaired kidney function.
Databáze: OpenAIRE
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