Efficacy of the ketogenic diet on ACTH- or corticosteroid-resistant infantile spasm: a multicentre prospective control study
| Autor: | Juan Wang, Fang Fang, Dongqing Zhang, Z. Liu, Chunhong Chen, Yi Wu, Baomin Li, Jie Zhang, Yanhui Chen, Li Jiang, Lifei Yu, Ye Wu, Guohong Chen, Jian Zha, J Peng, Jianmin Zhong, Fei Yin, Kaili Xu, Lijuan Huang, Yuwu Jiang, Shuizhen Zhou, Zhixian Yang |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Spasm medicine.drug_class medicine.medical_treatment Adrenocorticotropic hormone Gastroenterology Primary outcome Adrenocorticotropic Hormone Adrenal Cortex Hormones Internal medicine medicine Humans Prospective Studies business.industry Infant General Medicine Infantile Spasm medicine.disease Hypsarrhythmia Treatment Outcome Neurology Etiology Corticosteroid Anticonvulsants Neurology (clinical) medicine.symptom Ketosis business Diet Ketogenic Spasms Infantile Ketogenic diet |
| Zdroj: | Epileptic disorders : international epilepsy journal with videotape. 23(2) |
| ISSN: | 1950-6945 |
| Popis: | To determine the efficacy of ketogenic diet (KD) therapy on adrenocorticotropic hormone- (ACTH) or corticosteroid-resistant infantile spasm (IS), and identify relevant associated factors. A prospective controlled study was undertaken at 10 tertiary children's medical centres in mainland China. Participants were non-randomly assigned to KD therapy or control (adjustment of antiepileptic drugs). The primary outcome was the reduction in spasms and remission of hypsarrhythmia at the 16th week, divided into Grade I (spasm-free for at least one week with hypsarrhythmia remission), Grade II (≥50% spasm reduction and/or hypsarrhythmia remission) and Grade III ( |
| Databáze: | OpenAIRE |
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