Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9

Autor: Wei-Jen Chan, Jeng-Kai Jiang, Hsu Chun-Jieh, Chun-Wei Lee, Jen-Kuei Wu, Wei-Cheng Wu, Lu-Wei Chang, Hsueh-Yao Chu, Chien-Ping Lin, Ping-Hao Yeh, You-You Lyu, Fan-Gang Tseng, Chih-Yung Yang
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Oncology
Colorectal cancer
Embolism
Kaplan-Meier Estimate
prognostic analysis
Pattern Recognition
Automated
Metastasis
0302 clinical medicine
Circulating tumor cell
Carcinoembryonic antigen
Odds Ratio
Neoplasm Metastasis
Biology (General)
Immunoassay
biology
circulating tumor microemboli (CTM)
General Medicine
Middle Aged
Neoplastic Cells
Circulating
Prognosis
Phenotype
Lymphatic Metastasis
030220 oncology & carcinogenesis
Female
CTC clusters
CA19-9
circulating tumor cell (CTC)
Colorectal Neoplasms
Algorithms
medicine.medical_specialty
CA-19-9 Antigen
QH301-705.5
colorectal cancer (CRC)
Article
03 medical and health sciences
Internal medicine
Biomarkers
Tumor
medicine
Humans
Liquid biopsy
neoplasms
Aged
liquid biopsy
business.industry
Reproducibility of Results
Cancer
Odds ratio
medicine.disease
digestive system diseases
Carcinoembryonic Antigen
030104 developmental biology
Microscopy
Fluorescence
ROC Curve
biology.protein
Neoplasm Recurrence
Local
business
Zdroj: Cells, Vol 10, Iss 1149, p 1149 (2021)
Cells
Volume 10
Issue 5
ISSN: 2073-4409
DOI: 10.3390/cells10051149
Popis: Circulation tumor cells (CTCs) play an important role in metastasis and highly correlate with cancer progression
thus, CTCs could be considered as a powerful diagnosis tool. Our previous studies showed that the number of CTCs could be utilized for recurrence prediction in colorectal cancer (CRC)
however, the odds ratio was still lower than five. To improve prognosis in CRC patients, we analyzed CTC clusters/microemboli, CTC numbers, and carcinoembryonic antigen (CEA)/carbohydrate antigen 19-9 (CA19-9) levels using a self-assembled cell array (SACA) chip system for recurrence prediction. In CRC patients, the presence of CTC clusters/microemboli may have higher correlation in metastasis when compared to the high number of CTCs. Additionally, when both the number of CTCs and serum CEA levels are high, very high odds ratios of 24.4 and 17.1 are observed in patients at all stages and stage III of CRC, respectively. The high number of CTCs and CTC clusters/microemboli simultaneously suggests the high chance of relapse (odds ratio 8.4). Overall, the characteristic of CTC clusters/microemboli, CEA level, and CTC number have a clinical potential to enhance CRC prognosis.
Databáze: OpenAIRE
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