Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity
| Autor: | Danica Mihalova, Katarína Bauerová, Silvester Ponist, L Slovák, T. Fedorova, Viera Kuncirova |
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| Rok vydání: | 2016 |
| Předmět: |
030203 arthritis & rheumatology
0301 basic medicine Carnosine RM1-950 immune challenge Clinical study 03 medical and health sciences chemistry.chemical_compound kynurenine-3-monooxygenase 030104 developmental biology 0302 clinical medicine chemistry Biochemistry Immunity gender Therapeutics. Pharmacology Trolox General Pharmacology Toxicology and Pharmaceutics Derivative (chemistry) |
| Zdroj: | European Pharmaceutical Journal, Vol 63, Iss 1, Pp 16-19 (2016) |
| ISSN: | 2453-6725 |
| DOI: | 10.1515/afpuc-2016-0001 |
| Popis: | The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites. |
| Databáze: | OpenAIRE |
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