Pregabalin versus gabapentin in the treatment of sciatica: study protocol for a randomised, double-blind, cross-over trial (PAGPROS)
| Autor: | Kelvin Robertson, Linton Harriss, David Plummer, Maria Hennessy, Laurence A.G. Marshman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Gabapentin Visual analogue scale Pregabalin Medicine (miscellaneous) Pain Efficacy Study Protocol 03 medical and health sciences Sciatica 0302 clinical medicine Double-Blind Method medicine Protocol Humans Pharmacology (medical) Prospective Studies 030212 general & internal medicine Prospective cohort study Randomized Controlled Trials as Topic lcsh:R5-920 Cross-Over Studies business.industry Data Collection Crossover study Oswestry Disability Index Clinical trial Sample Size Physical therapy business lcsh:Medicine (General) 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Trials, Vol 19, Iss 1, Pp 1-10 (2018) Trials |
| ISSN: | 1745-6215 |
| DOI: | 10.1186/s13063-017-2400-y |
| Popis: | Background There is currently an absence of high-grade evidence regarding the treatment of chronic sciatica (CS). Whilst gabapentin (GBP) and pregabalin (PGB) are both currently used to treat CS, equipoise exists regarding their individual use. In particular, no head-to-head study of GBP and PGB in CS exists. Despite equipoise, most countries’ formulary regulatory authorities typically favour one drug for subsidy over the other. This hinders interchange wherever the favoured drug is either ineffective or not tolerated. The primary aim of this study is to conduct a head-to-head comparison of the efficacy of PGB versus GBP for CS based on outcomes on a visual analogue scale (VAS) and the Oswestry Disability Index (ODI). Methods/design We are conducting a prospective, randomised, double-blind, double-dummy cross-over study. Included patients will be over 18 years old and have unilateral CS with radiological confirmation of corresponding neural compression/irritation. Pregnant women, those with major organ disease, or those with creatinine clearance |
| Databáze: | OpenAIRE |
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