The Role of Mucosal Biopsy in the Diagnosis of Chronic Diarrhea: Value of Multiple Biopsies when Colonoscopic Finding is Normal or Nonspecific
| Autor: | Joungho Han, Seung Woon Paik, Poong-Lyul Rhee, Jong Chul Rhee, Howe J. Ree, Joon Hyoek Lee, Jae Jun Kim, Kwang Chul Koh |
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| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Diarrhea Male medicine.medical_specialty Pathology Lymphocytic colitis Histology Adolescent Colon Biopsy Rectum Gastroenterology Descending colon Internal medicine medicine Ascending colon Humans Prospective Studies Intestinal Mucosa Chronic diarrhea Aged Collagenous colitis medicine.diagnostic_test business.industry Sigmoid colon Colonoscopy Middle Aged medicine.disease Ulcerative colitis medicine.anatomical_structure Chronic Disease Original Article Female business |
| Zdroj: | The Korean Journal of Internal Medicine |
| ISSN: | 2005-6648 1226-3303 |
| Popis: | Objectives There are controversies about taking routine mucosal biopsy when the gross colonoscopic finding is normal. This study was conducted to determine the frequency of clinically important histological abnormalities, prospectively, in chronic diarrhea patients with grossly normal or nonspecific colonoscopic findings. Methods One hundred and eighteen patients suffering from nonbloody diarrhea with average frequency of more than two times a day for more than 4 weeks were included. Multiple biopsies (cecum, ascending colon, mid-transverse colon, descending colon, sigmoid colon and rectum) were taken during colonoscopic examinations and each biopsy specimen was reviewed by one pathologist after H&E and Masson-trichrome staining. Results Clinically significant abnormalities (2 collagenous colitis, 1 lymphocytic colitis, 1 eosinophilic enterocolitis, 1 ulcerative colitis and 4 melanosis coli) were observed in 9 patients (7.6%). Sixteen cases (13.6%) of borderline histological abnormalities were observed (8 cases of possible collagenous colitis and 8 cases showing some features of lymphocytic colitis). Ninety two cases (78.8%) showed nonspecific inflammation only. Conclusion Clinically important histological lesions can exist in significant percentage in spite of normal or nonspecific colonoscopic findings, which can justify routine mucosal biopsy in the evaluation of chronic diarrhea patients. The clinical significance of borderline histological abnormalities needs to be determined by careful follow-up studies. |
| Databáze: | OpenAIRE |
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