In vitro evaluation and in vivo demonstration of a biomimetic, hemocompatible, microfluidic artificial lung
| Autor: | Michael LaBarbera, Michelle Moyer, Brian L. Cmolik, E. van Lunteren, A. Sen Gupta, Kyle M. Kovach, Joseph A. Potkay, Jeffrey R. Capadona |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Materials science Microfluidics Biomedical Engineering Bioengineering Nanotechnology Biochemistry Rats sprague dawley Artificial lung Rats Sprague-Dawley Biomimetics In vivo PEG ratio Animals Lung Equipment Design General Chemistry Microfluidic Analytical Techniques Silicon Dioxide In vitro Rats Surface coating Artificial Organs Shear Strength Peg coating Biomedical engineering |
| Zdroj: | Lab on a Chip. 15:1366-1375 |
| ISSN: | 1473-0189 1473-0197 |
| DOI: | 10.1039/c4lc01284d |
| Popis: | Despite the promising potential of microfluidic artificial lungs, current designs suffer from short functional lifetimes due to surface chemistry and blood flow patterns that act to reduce hemocompatibility. Here, we present the first microfluidic artificial lung featuring a hemocompatible surface coating and a biomimetic blood path. The polyethylene-glycol (PEG) coated microfluidic lung exhibited a significantly improved in vitro lifetime compared to uncoated controls as well as consistent and significantly improved gas exchange over the entire testing period. Enabled by our hemocompatible PEG coating, we additionally describe the first extended (3 h) in vivo demonstration of a microfluidic artificial lung. |
| Databáze: | OpenAIRE |
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