A Rhabdomyosarcoma Arising in the Larynx of a Dog
| Autor: | Fumi Murai, Jyoji Yamate, Junichiro Shimizu, Takeshi Izawa, Mitsuru Kuwamura, Fumihito Ohashi, Hideo Akiyoshi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Larynx
larynx Pathology medicine.medical_specialty biology business.industry Vimentin Case Report Anatomy macromolecular substances Toxicology medicine.disease Stain Pathology and Forensic Medicine Cytokeratin Multinucleate medicine.anatomical_structure Cytoplasm dog medicine biology.protein Desmin rhabdomyosarcoma business Rhabdomyosarcoma |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 1881-915X 0914-9198 |
| Popis: | A neoplastic nodular lesion, 2 × 3 cm in diameter, was found in the larynx of a 6-year-old spayed female dog. The tumor was ill-circumscribed, consisting histologically of large round cells with abundant cytoplasm interspersed with small round cells with less cytoplasm and occasional multinucleated cells (myotubes). Immunohistochemically, tumor cells were positive for myoglobin, desmin and vimentin in varying degrees, but negative for S-100 protein, GFAP or cytokeratin. Cytoplasmic myofilaments/myofibrils with a dense Z-line-like structure were seen, the fine structures of which were complemented by PTAH stain. Based on these findings, the tumor was diagnosed as a rhabdomyosarcoma, a very rare tumor in the larynx of dogs. |
| Databáze: | OpenAIRE |
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