Add-On Effect of Bedtime Dosing of the .ALPHA.1-Adrenergic Receptor Antagonist Doxazosin on Morning Hypertension and Left Ventricular Hypertrophy in Patients Undergoing Long-Term Amlodipine Monotherapy
| Autor: | Yuko Shibuya, Shingo Shinozaki, Tomoko Gomi, Yoshifumi Suzuki, Toshio Ikeda, Nami Matsuda |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Physiology medicine.drug_class Blood Pressure Calcium channel blocker Left ventricular hypertrophy Essential hypertension Bedtime Internal medicine Internal Medicine medicine Doxazosin Humans Amlodipine Adrenergic alpha-Antagonists Triglycerides Aged Morning business.industry Middle Aged medicine.disease Cholesterol Endocrinology Blood pressure Hypertension Adrenergic alpha-1 Receptor Antagonists Cardiology Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Hypertension Research. 30:1097-1105 |
| ISSN: | 1348-4214 0916-9636 |
| DOI: | 10.1291/hypres.30.1097 |
| Popis: | High morning blood pressure is related to target organ damage and future cardiovascular events. Chronobiologic therapies focusing on the early morning period may be an important strategy for antihypertensive therapy. The aim of this study was to clarify the add-on effects of bedtime dosing of the alpha(1)-adrenergic receptor antagonist doxazosin on morning blood pressure in patients with essential hypertension who were under long-acting calcium channel blocker amlodipine monotherapy. The add-on effects of doxazosin at the maximum dose of 6 mg at bedtime on home blood pressure and left ventricular geometry for 1 year were investigated in 49 subjects (37 men and 12 women, aged 57.5+/-9.1 years) with morning hypertension who had been treated with amlodipine alone for more than 1 year. Doxazosin induced a significant decrease in morning blood pressure (145.6+/-5.6/91.5+/-5.4 to 132.4+/-3.7/83.6+/-5.6 mmHg, p |
| Databáze: | OpenAIRE |
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