Evaluating bionanoparticle infused fungal metabolites as a novel antimicrobial agent
| Autor: | Ram Prasad, Ajit Varma, Ramendra G Varma, Nafe Aziz, Kartikeya Rajpal |
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| Rok vydání: | 2016 |
| Předmět: |
Flavonoid
Bacillus cereus lcsh:RS1-441 02 engineering and technology 010402 general chemistry medicine.disease_cause 01 natural sciences Silver nanoparticle lcsh:Pharmacy and materia medica chemistry.chemical_compound medicine Aspergillus terreus Food science Phenols chemistry.chemical_classification biology lcsh:RM1-950 Pathogenic bacteria biogenic silver nanoparticle 021001 nanoscience & nanotechnology biology.organism_classification Antimicrobial 0104 chemical sciences Antibacterial lcsh:Therapeutics. Pharmacology chemistry Biochemistry Rann of Kutch Original Article 0210 nano-technology Antibacterial activity |
| Zdroj: | Journal of Advanced Pharmaceutical Technology & Research, Vol 7, Iss 3, Pp 110-114 (2016) Journal of Advanced Pharmaceutical Technology & Research |
| ISSN: | 2231-4040 |
| DOI: | 10.4103/2231-4040.184593 |
| Popis: | Therapeutic properties of fungal metabolites and silver nanoparticles have been well documented. While fungal metabolites have been used for centuries as medicinal drugs, potential of biogenic silver nanoparticles has recently received attention. We have evaluated the antimicrobial potential of Aspergillus terreus crude extract, silver nanoparticles and an amalgamation of both against four pathogenic bacterial strains. Antimicrobial activity of the following was evaluated – A. terreus extract, biogenic silver nanoparticles, and a mixture containing extract and nanoparticles. Four pathogenic bacteria - Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, and Bacillus cereus were used as test organisms. Phenol, flavonoid, and alkaloid content of extract were determined to understand the chemical profile of the fungus. The extract contained significantly high amounts of phenols, flavonoids, and alkaloids. The extract and biogenic silver nanoparticle exhibited significant antibacterial activity at concentrations of 10 μg/ml and 1 μg/ml, respectively. When used in combination, the extract-nanoparticle mixture showed equally potent antibacterial activity at a much lower concentration of 2.5 μg/ml extract + 0.5 μg/ml nanoparticle. Given its high antibacterial potential, the fungal extract can be a promising source of novel drug lead compounds. The extract – silver nanoparticle mixture exhibited synergism in their antibacterial efficacy. This property can be further used to formulate new age drugs. |
| Databáze: | OpenAIRE |
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