Chemical update on the potential for serotonin 5-HT6 and 5-HT7 receptor agents in the treatment of Alzheimer’s disease

Autor:	Kinga Czarnota, Hanna Baltrukevich, Katarzyna Kucwaj-Brysz, Jadwiga Handzlik
Rok vydání:	2021
Předmět:	Chemistry Organic Chemistry Clinical Biochemistry Central nervous system Pharmaceutical Science Disease Biochemistry 5-HT7 receptor Synthetic drugs Clinical trial medicine.anatomical_structure Drug Discovery medicine Molecular Medicine Serotonin Receptor Molecular Biology Neuroscience 5-HT receptor
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 49:128275
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2021.128275
Popis:	Despite the better understanding of the mechanisms underlying Alzheimer’s Disease (AD) and launched clinical trials, no AD-modifying treatment based on a synthetic drug has been introduced for almost twenty years. The serotonin 5-HT6 and 5-HT7 receptors turned out to be promising biological targets for modulation of central nervous system dysfunctions including cognitive impairment. Within this paper, we evaluate the pharmacological potency of both, 5-HT6R and 5-HT7R, agents in search for novel AD treatment. An overview of chemical structures of the 5-HTRs ligands with simultaneous procognitive action which have undergone preclinical and clinical studies within the last 10 years has been performed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa2be80ae45788451794bd875d00118 https://doi.org/10.1016/j.bmcl.2021.128275 Zobrazit plný text záznamu Full Text from ScienceDirect