Tolfenamic Acid Attenuates 3-Nitropropionic Acid-Induced Biochemical Alteration in Mice
| Autor: | Peng Liu, Tianyan Chi, Danyang Liu, Lin Li, Yinjie Li, Xuefei Ji, Libo Zou |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Genetically modified mouse medicine.medical_treatment Intraperitoneal injection Motor Activity Pharmacology Biochemistry Neuroprotection Antioxidants Mice 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Tolfenamic acid medicine Animals ortho-Aminobenzoates Chemistry Glutamate receptor Neurotoxicity General Medicine Nitro Compounds medicine.disease Oxidative Stress Neuroprotective Agents 030104 developmental biology Cytokine Cytokines NMDA receptor Neurotoxicity Syndromes Lipid Peroxidation Propionates 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | Neurochemical Research. 43:1938-1946 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/s11064-018-2615-7 |
| Popis: | Tolfenamic acid (TA), a nonsteroidal anti-inflammatory drug, shows neuroprotective effects and alleviates cognitive deficits in transgenic mouse models of Alzheimer's disease. However, whether TA can prevent the biochemical alterations induced by intraperitoneal injection of 3-nitropropionic acid (3-NP) in mice is still unknown. In this study, the striatal lesion area was measured by 2,3,5-triphenyltetrazolium chloride staining. Glutamate, SDH and ATP levels were tested using colorimetric assay kits. The neuroinflammatory cytokine levels were tested by ELISA kits. The expression of synaptic proteins and the subtypes of the NMDA receptor were tested by western blotting. TA was orally administered 10 days before 3-NP injection (pretreatment) or on the same day as 3-NP injection (co-treatment). TA pretreatment showed the strongest neuroprotective effects: pretreatment significantly attenuated the 3-NP-induced muscular weakness in the forelimb and alterations in glutamate level, mitochondrial function, and pro-inflammatory cytokine release in the brains of mice. These results suggest that TA has preventive and protective effects on 3-NP-induced neurotoxicity. |
| Databáze: | OpenAIRE |
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