Report of a series of 82 cases of Buruli ulcer from Nigeria treated in Benin, from 2006 to 2016

Autor: Julia Aguiar, Kingsley Asiedu, Yves Thierry Barogui, Jean Gabin Houezo, Anita Carolle Wadagni, Raoul Saizonou, Gilbert Adjimon Ayelo, Ghislain Emmanuel Sopoh, Ange Dodji Dossou, Roch Christian Johnson, Esai Anagonou
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Bacterial Diseases
Male
0301 basic medicine
Buruli ulcer
Pediatrics
Pathology and Laboratory Medicine
Medical Records
West africa
Geographical Locations
0302 clinical medicine
Interquartile range
Epidemiology
Medicine and Health Sciences
Benin
Medicine
Child
Buruli Ulcer
biology
lcsh:Public aspects of medicine
Neglected Diseases
Middle Aged
Hospitals
Actinobacteria
Infectious Diseases
Mycobacterium ulcerans
Female
Research Article
Neglected Tropical Diseases
Adult
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine
Patients
Adolescent
lcsh:RC955-962
030106 microbiology
030231 tropical medicine
Nigeria
Surgical and Invasive Medical Procedures
Young Adult
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
parasitic diseases
Humans
Retrospective Studies
Case detection
Bacteria
business.industry
Organisms
Public Health
Environmental and Occupational Health
Biology and Life Sciences
lcsh:RA1-1270
Tropical Diseases
medicine.disease
biology.organism_classification
Health Care
Health Care Facilities
People and Places
Africa
Lesions
business
Hospital stay
Zdroj: PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006358 (2018)
PLoS Neglected Tropical Diseases
ISSN: 1935-2735
1935-2727
Popis: Background Nigeria is one of the countries endemic for Buruli ulcer (BU) in West Africa but did not have a control programme until recently. As a result, BU patients often access treatment services in neighbouring Benin where dedicated health facilities have been established to provide treatment free of charge for BU patients. This study aimed to describe the epidemiological, clinical, biological and therapeutic characteristics of cases from Nigeria treated in three of the four treatment centers in Benin. Methodology/Principal findings A series of 82 BU cases from Nigeria were treated in three centres in Benin during 2006–2016 and are retrospectively described. The majority of these patients came from Ogun and Lagos States which border Benin. Most of the cases were diagnosed with ulcerative lesions (80.5%) and WHO category III lesions (82.9%); 97.5% were healed after a median hospital stay of 46 days (interquartile range [IQR]: 32–176 days). Conclusions/Significance This report adds to the epidemiological understanding of BU in Nigeria in the hope that the programme will intensify efforts aimed at early case detection and treatment.
Author summary Buruli ulcer (BU) is a neglected tropical disease that mainly affects the skin. The disease results from infection with Mycobacterium ulcerans, an environmental bacterium. In Benin, the BU treatment centres usually receive patients from Nigeria. In 2014, a study from one of the treatment centres (CDTUB, Pobe) which borders south-western Nigeria reported on a cohort of 127 PCR-confirmed cases between 2005 and 2013. We describe the epidemiological, clinical, biological and therapeutic characteristics of BU cases from Nigeria treated in the three other CDTUBs.
Databáze: OpenAIRE
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