Report of a series of 82 cases of Buruli ulcer from Nigeria treated in Benin, from 2006 to 2016
Autor: | Julia Aguiar, Kingsley Asiedu, Yves Thierry Barogui, Jean Gabin Houezo, Anita Carolle Wadagni, Raoul Saizonou, Gilbert Adjimon Ayelo, Ghislain Emmanuel Sopoh, Ange Dodji Dossou, Roch Christian Johnson, Esai Anagonou |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Bacterial Diseases
Male 0301 basic medicine Buruli ulcer Pediatrics Pathology and Laboratory Medicine Medical Records West africa Geographical Locations 0302 clinical medicine Interquartile range Epidemiology Medicine and Health Sciences Benin Medicine Child Buruli Ulcer biology lcsh:Public aspects of medicine Neglected Diseases Middle Aged Hospitals Actinobacteria Infectious Diseases Mycobacterium ulcerans Female Research Article Neglected Tropical Diseases Adult medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine Patients Adolescent lcsh:RC955-962 030106 microbiology 030231 tropical medicine Nigeria Surgical and Invasive Medical Procedures Young Adult 03 medical and health sciences Signs and Symptoms Diagnostic Medicine parasitic diseases Humans Retrospective Studies Case detection Bacteria business.industry Organisms Public Health Environmental and Occupational Health Biology and Life Sciences lcsh:RA1-1270 Tropical Diseases medicine.disease biology.organism_classification Health Care Health Care Facilities People and Places Africa Lesions business Hospital stay |
Zdroj: | PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006358 (2018) PLoS Neglected Tropical Diseases |
ISSN: | 1935-2735 1935-2727 |
Popis: | Background Nigeria is one of the countries endemic for Buruli ulcer (BU) in West Africa but did not have a control programme until recently. As a result, BU patients often access treatment services in neighbouring Benin where dedicated health facilities have been established to provide treatment free of charge for BU patients. This study aimed to describe the epidemiological, clinical, biological and therapeutic characteristics of cases from Nigeria treated in three of the four treatment centers in Benin. Methodology/Principal findings A series of 82 BU cases from Nigeria were treated in three centres in Benin during 2006–2016 and are retrospectively described. The majority of these patients came from Ogun and Lagos States which border Benin. Most of the cases were diagnosed with ulcerative lesions (80.5%) and WHO category III lesions (82.9%); 97.5% were healed after a median hospital stay of 46 days (interquartile range [IQR]: 32–176 days). Conclusions/Significance This report adds to the epidemiological understanding of BU in Nigeria in the hope that the programme will intensify efforts aimed at early case detection and treatment. Author summary Buruli ulcer (BU) is a neglected tropical disease that mainly affects the skin. The disease results from infection with Mycobacterium ulcerans, an environmental bacterium. In Benin, the BU treatment centres usually receive patients from Nigeria. In 2014, a study from one of the treatment centres (CDTUB, Pobe) which borders south-western Nigeria reported on a cohort of 127 PCR-confirmed cases between 2005 and 2013. We describe the epidemiological, clinical, biological and therapeutic characteristics of BU cases from Nigeria treated in the three other CDTUBs. |
Databáze: | OpenAIRE |
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