Systemic acidemia impairs cardiac function in critically Ill patients
| Autor: | P Eiben, S Vanapalli, A Spataru, C Harris, Sancho Rodríguez-Villar, I Awad, J Arévalo-Serrano, L Thompson, B Gurung, V Recea, S G Sakka, C Brathwaite-Shirley, J A Kraut, A Collins, R Reece-Anthony, M Toolan |
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| Rok vydání: | 2020 |
| Předmět: |
Cardiac function curve
Cardiac output medicine.medical_specialty Medicine (General) PiCCO 01 natural sciences law.invention ABG-a 03 medical and health sciences 0302 clinical medicine R5-920 law Intensive care Internal medicine medicine Arterial pH 030212 general & internal medicine 0101 mathematics GEF Transpulmonary thermodilution Acidosis dPmx Acidemia Point-of-Care arterial blood gas business.industry Critically ill pH 010102 general mathematics Cardiac function General Medicine CI Intensive care unit CO Critical care Cardiac contractility Cardiology CPI Thermodilution technique SVI CFI medicine.symptom business Research Paper |
| Zdroj: | EClinicalMedicine EClinicalMedicine, Vol 37, Iss, Pp 100956-(2021) |
| ISSN: | 2589-5370 |
| Popis: | Background: Acidemia, is associated with reduced cardiac function in animals, but no studies showing an effect of acidemia on cardiac function in humans are reported. In the present study, we examined the effect of acidemia on cardiac function assessed with transpulmonary thermodilution technique with integrated pulse contour analysis (Pulse Contour Cardiac Output, PiCCO™) in a large cohort of critically ill patients. Methods: This was a prospective multicenter observational cross-sectional study of 297 patients from 6 intensive care units in London, England selected from all patients admitted consecutively between May 2018 and March 2019. Measurements of lowest plasma pH and concurrent assessment of cardiac function were obtained. Findings: There was a significant difference between two pH categories (pH ≤ 7.28 vs. pH > 7.28) for the following variables of cardiac function: SVI (difference in means 32.7; 95% CI: 21 to 45 mL/m2; p |
| Databáze: | OpenAIRE |
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