An Evidence-Based Review of Galcanezumab for the Treatment of Migraine
Autor: | Omar Viswanath, Amnon A Berger, Elyse M. Cornett, Michael C Swett, Ivan Urits, Melis Yilmaz, Karina Charipova, Hisham Kassem, Ehab Bahrum, Anh L. Ngo, Alan D. Kaye, Kyle Gress |
---|---|
Rok vydání: | 2020 |
Předmět: |
Monoclonal antibody
medicine.medical_specialty Neurology Population Chronic pain Review Calcitonin gene-related peptide 03 medical and health sciences 0302 clinical medicine Epidemiology medicine Prevention of migraines CGRP 030212 general & internal medicine Migraine treatment RC346-429 education Intensive care medicine Migraine education.field_of_study business.industry Headache medicine.disease Galcanezumab Neurology. Diseases of the nervous system Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | Neurology and Therapy Neurology and Therapy, Vol 9, Iss 2, Pp 403-417 (2020) |
ISSN: | 2193-6536 2193-8253 |
DOI: | 10.1007/s40120-020-00214-3 |
Popis: | Purpose of Review This is a comprehensive review of the current literature on the usage of galcanezumab for migraine treatment. It reviews the biology, pathophysiology, epidemiology, diagnosis, and conventional treatment of migraines, then compares the literature available for galcanezumab with historical treatment options. Recent Findings Migraine is a common headache disorder and constitutes a significant source of distress from both a personal and societal perspective. Conventional treatment includes abortive and preventive treatment. Treatment options are limited and may be only partially or minimally effective in some of the population. Recent evidence points to metabolic changes in the brain as possible causes of migraine, via reduced available energy or a spiking need for it, resulting in a relative insufficiency. This leads to trigeminocervical complex (TCC) activation and a headache episode, modulated by calcitonin gene-related peptide (CGRP). Galcanezumab (Emgality) is a monoclonal antibody targeting CGRP that is given in a monthly injection for the prevention of migraines. Its safety was previously shown in phase 1 and 2 trials, and recent phase 3 trials showed efficacy, with up to 50% reduction in monthly migraine days and improved functional capacity in migraineurs. Studies show that the drug is well tolerated and safe. Summary Migraine headache is a common neurological syndrome that causes great pain and suffering. Treatment options today are limited. Galcanezumab does not prevent migraines, but it is effective in decreasing their frequency and length. It is also much better tolerated than the currently existing therapies. While it is unlikely to provide monotherapy for migraines, it is a novel therapy that may be added for cases of severe or frequent migraines. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |