Kidney-liver pathophysiological crosstalk: its characteristics and importance
| Autor: | Alberta Ferrero-Fernández, Olivia Maria Capalbo, Sofía Giuliani, Carlos G. Musso, Paola Casciato |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Nephrology medicine.medical_specialty Pathology LIVER CIENCIAS MÉDICAS Y DE LA SALUD Urology 030232 urology & nephrology CROSSTALK Medicina Clínica Lung injury Kidney 03 medical and health sciences 0302 clinical medicine KIDNEY Internal medicine medicine Humans Autoregulation Lung business.industry Liver Diseases Acute kidney injury respiratory system Acute Kidney Injury Pulmonary edema medicine.disease respiratory tract diseases Urología y Nefrología 030104 developmental biology medicine.anatomical_structure Respiratory failure Liver Cardiology business |
| Zdroj: | International urology and nephrology. 51(12) |
| ISSN: | 1573-2584 |
| Popis: | The kidney plays a crucial role in controlling the blood volume and pressure, electrolyte and acid–base balance, erythropoietin secretion, as well as renin–angiotensin–aldosterone system activity. All these renal activities have important repercussion in the organism, explaining why morbidity and mortality rates are high in patients with significant renal dysfunction. In this sense, there are renal-induced liver damages in acute kidney injury, as well as liver-induced renal damages in hepatic disease. Ischemia, reperfusion, cytokine outflow, pro-inflammatory cascades, metabolic acidosis, oxidative stress, and changes in enzymatic and metabolic pathways provide the bases for this bidirectional kidney–liver damage. In conclusion, knowing the characteristics of this kidney–liver crosstalk is crucial for handling the complications induced by this vicious circle. Fil: Capalbo, Olivia. Hospital Italiano; Argentina Fil: Giuliani, Sofía. Hospital Italiano; Argentina Fil: Ferrero-Fernández, Alberta. Hospital Italiano; Argentina Fil: Casciato, Paola. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina Fil: Musso, Carlos. Hospital Italiano; Argentina |
| Databáze: | OpenAIRE |
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