Early replication and expression of oocyte-type 5S RNA genes in a Xenopus somatic cell line carrying a translocation
| Autor: | L J Korn, B A Hamkalo, J Y Tso, S Narayanswami, D R Guinta |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Cell division
Somatic cell Xenopus Biology Translocation Genetic Cell Line Xenopus laevis Transcription Factor TFIIIA Gene expression Animals Interphase Transcription factor Gene Genetics Multidisciplinary Models Genetic RNA biology.organism_classification Gene Expression Regulation RNA Ribosomal Oocytes Female Cell Division Research Article Transcription Factors |
| Zdroj: | Proceedings of the National Academy of Sciences. 83:5150-5154 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | In Xenopus somatic cells, the somatic-type 5S RNA genes replicate early in S phase, bind the transcription factor TFIIIA, and are expressed; in contrast, the late replicating oocyte-type genes do not bind TFIIIA and are transcriptionally inactive. These facts support a model in which the order of replication of the somatic-type versus the oocyte-type 5S genes causes their differential expression in somatic cells due to sequestration of TFIIIA by the early-replicating somatic genes. Here we provide further evidence for the model by showing that in one Xenopus cell line in which some oocyte-type 5S genes are translocated, some oocyte-type 5S genes replicate early and are expressed. |
| Databáze: | OpenAIRE |
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