Gender differences in UV-induced skin inflammation, skin carcinogenesis and systemic damage
| Autor: | Yun-Nan Zou, Wei-Peng Feng, Bing Lin, Yin-Ting Chen, Yu Liu, Qing-Yuan Zhong, Yin-Ping Huang, Baoqin Lin, Gui-Hong Long, Nian-Li Sang, Ying Wu, Janis Ya-Xian Zhan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Carcinogenesis Ultraviolet Rays Health Toxicology and Mutagenesis Photoaging Physiology Inflammation Thymus Gland 010501 environmental sciences Kidney Toxicology medicine.disease_cause Systemic inflammation 01 natural sciences Mice 03 medical and health sciences Internal medicine medicine Animals Skin 030304 developmental biology 0105 earth and related environmental sciences Pharmacology Sex Characteristics 0303 health sciences Hematology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Cancer General Medicine medicine.disease Oxidative Stress Liver Female Skin cancer medicine.symptom Reactive Oxygen Species business Spleen Oxidative stress |
| Zdroj: | Environmental Toxicology and Pharmacology. 81:103512 |
| ISSN: | 1382-6689 |
| DOI: | 10.1016/j.etap.2020.103512 |
| Popis: | Ultraviolet (UV) radiation-induced chronic inflammation contributes to all stages of skin tumor development. In addition, gender plays an important role in inflammatory diseases or cancer. In this study, histopathology changes, hematology, oxidative stress and inflammatory response were used to evaluate sex differences in UV-induced chronic inflammation-associated cancer development. The results showed that the male and female mice had photoaging damage at the 9th week. However, skin tumors only appeared in male mice at 31st week. Furthermore, UV increased ROS production, p65, p-p65, IL-6 and TNF-α protein expressions in skin, and these factors elevated more in male mouse model. Hematology results showed that the parameters of blood systemic inflammation were changed in different degrees in model groups, while the pathological results showed inflammatory cell infiltration in the internal organs of both model groups in varying degrees. These results indicate that there are gender differences in UV-induced skin inflammation, carcinogenesis and systemic damage. Moreover, male mice are more sensitive to UV irradiation, which may be responsible to greater oxidative stress and inflammatory damage. |
| Databáze: | OpenAIRE |
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