In vitro andin vivo comparison of creams containing dithranol 0.5%
| Autor: | Y. G. Van Der Meer, J. J. W. Ros, W. J. A. De Kort, P. Van Andel, D. De Hoop |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Pharmacology Ointments Silicon membrane Double-Blind Method In vivo Psoriasis Dithranol medicine Animals Humans Pharmacology (medical) Clinical efficacy business.industry Penetration (firestop) Anthralin medicine.disease In vitro Skin irritation Solubility Irritants Female Rabbits business medicine.drug |
| Zdroj: | Pharmaceutisch Weekblad. 13:210-214 |
| ISSN: | 1573-739X 0031-6911 |
| DOI: | 10.1007/bf01988877 |
| Popis: | In an in vitro model, the release and penetration through a silicon membrane of different cream formulations and ointments containing 0.5% dithranol were studied. The results indicated that the method is not suitable for predicting in vivo release and penetration. Experiments with rabbits showed that the degree of skin irritation produced by a hospital-prepared product containing 0.5% dithranol was comparable to that of of a commercial product. Clinical efficacy and side-effects of these two products were investigated in a double-blind left-right comparative study in 35 patients with chronic plaque psoriasis. The two creams proved to be equally effective and showed the same incidence of side-effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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