Synaptic Properties of Connections between the Primary and Secondary Auditory Cortices in Mice
| Autor: | Elise N. Covic, S. Murray Sherman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Auditory Cortex
Patch-Clamp Techniques Cognitive Neuroscience Feature Article Glutamic Acid Biology Neurotransmission Synaptic Potentials Synaptic Transmission Cellular and Molecular Neuroscience Mice Synaptic fatigue Metabotropic glutamate receptor Postsynaptic potential Synaptic augmentation Synaptic plasticity Neural Pathways Synapses Excitatory postsynaptic potential Ionotropic glutamate receptor Animals Neuroscience |
| Popis: | Little is known regarding the synaptic properties of corticocortical connections from one cortical area to another. To expand on this knowledge, we assessed the synaptic properties of excitatory projections from the primary to secondary auditory cortex and vice versa. We identified 2 types of postsynaptic responses. The first class of responses have larger initial excitatory postsynaptic potentials (EPSPs), exhibit paired-pulse depression, are limited to ionotropic glutamate receptor activation, and have larger synaptic terminals; the second has smaller initial EPSPs, paired-pulse facilitation, metabotropic glutamate receptor activation, and smaller synaptic terminals. These responses are similar to the driver and modulator properties previously identified for thalamic and thalamocortical circuitry, suggesting that the same classification may extend to corticocortical inputs and have an implication for the functional organization of corticocortical circuits. |
| Databáze: | OpenAIRE |
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