Cancer risk in patients with hepatitis C virus infection: a population‐based study in Sweden

Autor:	Xiaohua Dong, Xiangdong Liu, Junming Wang, Yanqing Chen, Youxin Wang, Jianguang Ji, Jianhua Tang, Kristina Sundquist, Jan Sundquist
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	hepatitis C virus Adult Male Cancer Research medicine.medical_specialty Hepatitis C virus medicine.disease_cause 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Stage (cooking) Original Research Cancer risk Sweden business.industry Melanoma Incidence (epidemiology) Incidence Liver Neoplasms Hepatitis C Middle Aged medicine.disease Oncology 030220 oncology & carcinogenesis Immunology 030211 gastroenterology & hepatology Female Liver cancer business Cancer Prevention
Zdroj:	Cancer Medicine
ISSN:	2045-7634
Popis:	Increased risks of certain cancers have been observed in patients with hepatitis C virus (HCV) infection. However, data on other cancer sites/types are lacking. We analyzed systematically the risk of developing 35 common cancers in patients with HCV infection using a nationwide Swedish database. Patients with HCV infection were identified from the Swedish Hospital Inpatient and Outpatient Register and Primary Health Care Database, and followed until the diagnosis of cancer. Standardized incidence ratios (SIRs) were calculated for subsequent 35 common cancer sites/types between 1990 and 2010 in patients with HCV infection in Sweden. Increased risks were recorded for six cancers. The highest SIR was seen for liver cancer (36.67; 95% CI: 33.20–40.40). The decreased risk was for prostate cancer (0.73; 95% CI: 0.59–0.90) and melanoma (0.50; 95% CI: 0.30–0.79). A significant sex‐difference for cancer was observed only for liver cancer (40.72; 95% CI: 36.36–45.45 for men and 27.21; 95% CI: 21.90–33.41 for women). Also, increased SIRs were noted only for liver cancer during the entire period of follow‐up. HCV infection was associated with an increased incidence of liver cancer and additionally five other types of cancer. Active surveillance of other cancers may be needed in order to be diagnosed at an earlier stage.
Databáze:	OpenAIRE
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