Regional Brain Gray Matter Changes in Patients with Type 2 Diabetes Mellitus
| Autor: | Mary A. Woo, Sarah E. Choi, Rajesh Kumar, Luke Ehlert, Bhaswati Roy, Rashmi S. Mullur, Matthew J. Freeby |
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| Rok vydání: | 2020 |
| Předmět: |
Male
endocrine system diseases Beck Anxiety Inventory lcsh:Medicine 0302 clinical medicine 2.1 Biological and endogenous factors Aetiology Gray Matter lcsh:Science Brain Mapping Multidisciplinary Depression Incidence Diabetes Brain Montreal Cognitive Assessment Cognition Middle Aged Prognosis Los Angeles Magnetic Resonance Imaging Mental Health Neurological Anxiety Female Medical imaging medicine.symptom Type 2 medicine.medical_specialty 030209 endocrinology & metabolism Brain damage Article 03 medical and health sciences Clinical Research Internal medicine Behavioral and Social Science Diabetes Mellitus medicine Humans Cognitive Dysfunction business.industry lcsh:R Neurosciences Health care Brain Disorders Endocrinology Mood Diabetes Mellitus Type 2 nervous system Case-Control Studies lcsh:Q Brain Gray Matter business Insula 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Scientific Reports Scientific reports, vol 10, iss 1 Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-67022-5 |
| Popis: | Patients with Type 2 diabetes mellitus (T2DM) show cognitive and mood impairment, indicating potential for brain injury in regions that control these functions. However, brain tissue integrity in cognition, anxiety, and depression regulatory sites, and their associations with these functional deficits in T2DM subjects remain unclear. We examined gray matter (GM) changes in 34 T2DM and 88 control subjects using high-resolution T1-weighted images, collected from a 3.0-Tesla magnetic resonance imaging scanner, and assessed anxiety [Beck Anxiety Inventory], depressive symptoms [Beck Depression Inventory-II], and cognition [Montreal Cognitive Assessment]. We also investigated relationships between GM status of cognitive and mood control sites and these scores in T2DM. Significantly increased anxiety (p = 0.003) and depression (p = 0.001), and reduced cognition (p = 0.002) appeared in T2DM over controls. Decreased GM volumes appeared in several regions in T2DM patients, including the prefrontal, hippocampus, amygdala, insular, cingulate, cerebellum, caudate, basal-forebrain, and thalamus areas (p |
| Databáze: | OpenAIRE |
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