Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling
| Autor: | Manli Yang, Bijie Jiang, Weidong Wu, Hassan Ahmed, Zhenquan Jia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Diesel exhaust lcsh:Medicine Review Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound In vivo Humans Cytotoxicity Vehicle Emissions Pollutant chemistry.chemical_classification Reactive oxygen species Air Pollutants General Immunology and Microbiology lcsh:R General Medicine Glutathione Phenanthrenes In vitro 030104 developmental biology chemistry Phase II Detoxification Biophysics Reactive Oxygen Species Oxidation-Reduction |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2018 (2018) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Atmospheric pollution has been a principal topic recently in the scientific and political community due to its role and impact on human and ecological health. 9,10-phenanthrenequinone (9,10-PQ) is a quinone molecule found in air pollution abundantly in the diesel exhaust particles (DEP). This compound has studied extensively and has been shown to develop cytotoxic effects both in vitro and in vivo. 9, 10-PQ has been proposed to play a critical role in the development of cytotoxicity via generation of reactive oxygen species (ROS) through redox cycling. This compound also reduces expression of glutathione (GSH), which is critical in Phase II detoxification reactions. Understanding the underlying cellular mechanisms involved in cytotoxicity can allow for the development of therapeutics designed to target specific molecules significantly involved in the 9,10-PQ-induced ROS toxicity. This review highlights the developments in the understanding of the cytotoxic effects of 9, 10-PQ with special emphasis on the possible mechanisms involved. |
| Databáze: | OpenAIRE |
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