Antiproliferative Activity of Natural Taiwaniaquinoids and Related Compounds
| Autor: | Soumicha Mahdjour, Juan J. Guardia, Rubén Tapia, Fernando Rodríguez-Serrano, Nuria Mut-Salud, Rachid Chahboun, Enrique Alvarez-Manzaneda |
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| Rok vydání: | 2017 |
| Předmět: |
Stereochemistry
Taiwan Substituent Cytostatic agents Pharmaceutical Science Antineoplastic Agents Tumor cells 010402 general chemistry 01 natural sciences Analytical Chemistry chemistry.chemical_compound Drug Discovery medicine Humans Cell Proliferation Pharmacology Lung Molecular Structure Terpenes 010405 organic chemistry Organic Chemistry Stereoisomerism In vitro 0104 chemical sciences Lung cancer cell medicine.anatomical_structure Complementary and alternative medicine chemistry Cell culture MCF-7 Cells Cancer research Molecular Medicine Female Drug Screening Assays Antitumor Human breast |
| Zdroj: | Journal of Natural Products. 80:308-318 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.6b00700 |
| Popis: | The in vitro antiproliferative activities of some taiwaniaquinoids and related compounds with functionalized A, B, or C rings against human breast (MCF-7), colon (T-84), and lung (A-549) tumor cell lines were assayed. The most potent compounds, 16, 27, and 36, were more effective than the naturally occurring taiwaniaquinones A (4) and F (5) in all three cell lines. The structure-activity relationship study of these new taiwaniaquinoids highlighted the correlation between the bromo substituent and the antiproliferative activity, especially in MCF-7 cells. These findings indicate that some of the taiwaniaquinoids might be useful as cytostatic agents against breast, colon, and lung cancer cell lines. |
| Databáze: | OpenAIRE |
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