Dosimetric parameters predict radiation-induced choanal stenosis in patients with nasopharyngeal carcinoma

Autor: Yuanhong Gao, Hui Chang, Yalan Tao, Fei Han, Kai Chen, Wei-Jun Ye
Jazyk: angličtina
Rok vydání: 2020
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
Nasal cavity
Adult
Male
lcsh:R895-920
medicine.medical_treatment
Constriction
Pathologic
lcsh:RC254-282
Choanal stenosis
03 medical and health sciences
Young Adult
0302 clinical medicine
hemic and lymphatic diseases
Nasopharynx
Mucositis
otorhinolaryngologic diseases
Cutoff
Medicine
Humans
Radiology
Nuclear Medicine and imaging
030212 general & internal medicine
Radiation Injuries
Radiometry
Aged
Retrospective Studies
Nasopharyngeal Carcinoma
RICS
Radiotherapy
business.industry
Research
Radiation dose
Nasopharyngeal Neoplasms
Radiotherapy Dosage
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Radiation therapy
medicine.anatomical_structure
Oncology
Nasopharyngeal carcinoma
030220 oncology & carcinogenesis
Female
business
Nuclear medicine
Zdroj: Radiation Oncology (London, England)
Radiation Oncology, Vol 15, Iss 1, Pp 1-7 (2020)
ISSN: 1748-717X
Popis: Background Radiation-induced choanal stenosis (RICS) severely decreases life quality of patients with nasopharyngeal carcinoma (NPC) and originates from nasal mucositis, which depends on radiation dose. This self-controlled study aimed to find the correlations between dosimetric parameters and RICS. Methods Totally 49 NPC patients treated with intensity-modulated radiotherapy from May 2010 to Aug. 2013 and diagnosed with RICS during follow-up were enrolled into this study. Minimum point dose, maximum point dose, mean dose (Dmean), dose covering ≥33% volume (D33), dose covering ≥66% volume (D66), and volume receiving ≥60 Gy (V60) were compared between the nasal cavities with and without RICS, through paired t-test. The parameters with difference would enter receiver operating characteristic analysis to determine their cutoff values. Then predicting abilities of the cutoff values were tested by Chi-square test. Result The nasal cavities with RICS appeared to have higher Dmean, D33, D66 and V60, compared with those without RICS (P values were 0.014, 0.003, 0.006 and 0.010). Dmean ≥54.22 Gy, D33 ≥ 61.96 Gy, D66 ≥ 46.50 Gy and V60 ≥ 48.13% were demonstrated to be related with a higher risk of RICS. Conclusion Dmean, D33, D66 and V60 of nasal cavity might be used as predictors of RICS. Their values needed to be controlled whenever possible, for ameliorating life quality of NPC patients.
Databáze: OpenAIRE
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