Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
| Autor: | Inés Rebagliati, C. R. Ricci, Angel A. Zaninovich, Karl Hagmüller, Marcela Raices |
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| Rok vydání: | 2002 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors endocrine system diseases Physiology Endocrinology Diabetes and Metabolism Acclimatization Thyroid Gland Biology Ion Channels Mitochondrial Proteins Oxygen Consumption Adipose Tissue Brown Antithyroid Agents Hypothyroidism Physiology (medical) Internal medicine Brown adipose tissue medicine Cold acclimation Uncoupling protein Animals RNA Messenger Rats Wistar Uncoupling Protein 1 Methimazole Thyroid Body Weight Glyceraldehyde-3-Phosphate Dehydrogenases Membrane Proteins Thermogenesis Thermogenin Mitochondria Rats Cold Temperature Isoenzymes medicine.anatomical_structure Endocrinology Female Thyroid function Carrier Proteins Hormone |
| Zdroj: | American journal of physiology. Endocrinology and metabolism. 283(3) |
| ISSN: | 0193-1849 |
| Popis: | The effects of long-term cold exposure on brown adipose tissue (BAT) thermogenesis in hypothyroid rats have been examined. Thyroid ablation was performed in normal rats after 2 mo of exposure to 4°C, when BAT hypertrophy and thermogenic activity were maximal. After ablation, hypothyroid and normal controls remained in the cold for 2 additional months. At the end of the 4-mo cold exposure, all untreated hypothyroid rats were alive, had normal body temperature, and had gained an average 12.8% more weight than normal controls. Long-term cold exposure of hypothyroid rats markedly increased BAT weight, mitochondrial proteins, uncoupling protein (UCP)-1, mRNA for UCP-1, and oxygen consumption to levels similar to those seen in cold-exposed normal rats. The results indicate that thyroid hormones are required for increased thermogenic capacity to occur as an adaptation to long-term cold exposure. However, cold adaptation can be maintained in the absence of thyroid hormone. |
| Databáze: | OpenAIRE |
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