Properties and in vitro drug release of pH- and temperature-sensitive double cross-linked interpenetrating polymer network hydrogels based on hyaluronic acid/poly (N-isopropylacrylamide) for transdermal delivery of luteolin
| Autor: | A Rang Kim, Soo Nam Park, Sang Lae Lee |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Keratinocytes
Hot Temperature Swine Skin Absorption Radical polymerization Acrylic Resins macromolecular substances 02 engineering and technology Administration Cutaneous 010402 general chemistry 01 natural sciences Biochemistry chemistry.chemical_compound Structural Biology medicine Animals Interpenetrating polymer network Hyaluronic Acid Luteolin Molecular Biology Transdermal technology industry and agriculture Hydrogels General Medicine Permeation 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Chemical engineering Delayed-Action Preparations Self-healing hydrogels Poly(N-isopropylacrylamide) Swine Miniature Swelling medicine.symptom 0210 nano-technology |
| Zdroj: | International Journal of Biological Macromolecules. 118:731-740 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2018.06.061 |
| Popis: | In this study, we prepared double cross-linked interpenetrating polymer network (IPN) hydrogels composed of temperature sensitive poly (N-isopropylacrylamide) (PNIPAM) and pH sensitive hyaluronic acid (HA) by radical polymerization and Michael addition. Their physicochemical properties for transdermal delivery of luteolin inhibiting the hyperproliferation of keratinocytes in psoriasis were investigated and drug release studies were performed. Double networks of HA/PNIPAM IPN hydrogel were identified through FT-IR and 13CNMR. By measuring the swelling ratios pH and temperature sensitivity were confirmed, and it was influenced by the content of a cross-linking agent. As a result of texture analysis and rheometry, a IPN hydrogel with 3% crosslinker content had the most adhesive and stable cross-linked network. Therefore, luteolin was loaded on this hydrogel. Its drug release behavior was determined at various temperatures and pH using several drug release kinetic models. As a result of skin permeation study, HA/PNIPAM IPN hydrogel effectively delivers luteolin to the epidermis and dermis. No toxicity was observed as a result of observing cytotoxicity of the hydrogel for application to the skin. In conclusion, IPN hydrogels can be developed as carriers of transdermal delivery system of luteolin for psoriasis skin relief. |
| Databáze: | OpenAIRE |
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