SATB1-mediated chromatin landscape in T cells
| Autor: | Charalampos G. Spilianakis, Tomas Zelenka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Gene isoform
CD4-Positive T-Lymphocytes lcsh:QH426-470 Review Biology CD8-Positive T-Lymphocytes t cell receptor Autoimmune Diseases 03 medical and health sciences Mice Neoplasms Transcriptional regulation Biomarkers Tumor Animals Humans cancer cd4 cells lcsh:QH573-671 Gene 030304 developmental biology Regulation of gene expression 0303 health sciences lcsh:Cytology 030302 biochemistry & molecular biology T-cell receptor autoimmunity Cell Biology SATB1 Matrix Attachment Region Binding Proteins Review - Invited Chromatin Cell biology Neoplasm Proteins lcsh:Genetics thymocytes nuclear matrix phase separation satb1 CD8 chromatin organization |
| Zdroj: | Nucleus, Vol 11, Iss 1, Pp 117-131 (2020) Nucleus article-version (VoR) Version of Record |
| ISSN: | 1949-1042 1949-1034 |
| Popis: | The regulatory circuits that define developmental decisions of thymocytes are still incompletely resolved. SATB1 protein is predominantly expressed at the CD4+CD8+cell stage exerting its broad transcription regulation potential with both activatory and repressive roles. A series of post-translational modifications and the presence of potential SATB1 protein isoforms indicate the complexity of its regulatory potential. The most apparent mechanism of its involvement in gene expression regulation is via the orchestration of long-range chromatin loops between genes and their regulatory elements. Multiple SATB1 perturbations in mice uncovered a link to autoimmune diseases while clinical investigations on cancer research uncovered that SATB1 has a promoting role in several types of cancer and can be used as a prognostic biomarker. SATB1 is a multivalent tissue-specific factor with a broad and yet undetermined regulatory potential. Future investigations on this protein could further uncover T cell-specific regulatory pathways and link them to (patho)physiology. |
| Databáze: | OpenAIRE |
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