Functional Improvement of Tacrolimus-Induced Parkinsonism With Amantadine After Liver Transplantation: A Case Report
| Autor: | Peter Yonclas, Nicole Diaz-Segarra, Arline Edmond |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty medicine.medical_treatment Liver transplantation Tacrolimus Parkinsonian Disorders Quality of life Amantadine medicine Hospital discharge Humans Pharmacology (medical) Pharmacology business.industry Parkinsonism Middle Aged medicine.disease Gait Dysphagia Liver Transplantation surgical procedures operative Quality of Life Neurology (clinical) medicine.symptom business Immunosuppressive Agents medicine.drug |
| Zdroj: | Clinical Neuropharmacology. 44:141-144 |
| ISSN: | 1537-162X 0362-5664 |
| Popis: | Drug-induced parkinsonism is the most common type of drug-induced movement disorder, whose symptoms can decrease patient quality of life and reduce medication compliance. Tacrolimus is a routinely used immunosuppressant agent after liver transplantation, with a well-known neurotoxic profile. There have been rare reports of tacrolimus-induced parkinsonism, but its pharmacologic management and functional impact remain poorly characterized in the literature. We present a case of tacrolimus-induced parkinsonism in a 62-year-old man after a liver transplant, resulting in significant neurologic impairments and multiple barriers to hospital discharge. His tremor, rigidity, bradykinesia, gait dysfunction, dysphonia, and dysphagia significantly improved after starting low-dose amantadine, with increased functional independence that allowed for a safe discharge. This is the first case in the literature detailing tacrolimus-induced parkinsonism's functional impairments improving with amantadine monotherapy. |
| Databáze: | OpenAIRE |
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