Consistent altered internal capsule white matter microstructure in insomnia disorder
Autor: | Jennifer R Ramautar, Rick Wassing, Eus J.W. Van Someren, Jessica C. Foster-Dingley, Tom Bresser, Diederick Stoffers, Oti Lakbila-Kamal, Jeanne Leerssen, Martijn P. van den Heuvel |
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Přispěvatelé: | Spinoza Centre for Neuroimaging, Netherlands Institute for Neuroscience (NIN), Complex Trait Genetics, Integrative Neurophysiology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Human genetics, Psychiatry, APH - Mental Health |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Right internal capsule
medicine.medical_specialty Internal capsule Gastroenterology White matter 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Internal Capsule Physiology (medical) Internal medicine Sleep Initiation and Maintenance Disorders Fractional anisotropy mental disorders medicine Insomnia Humans internal capsule AcademicSubjects/MED00385 medicine.diagnostic_test business.industry AcademicSubjects/SCI01870 Brain Magnetic resonance imaging diffusion tensor imaging White matter microstructure White Matter 030227 psychiatry medicine.anatomical_structure Insomnia and Psychiatric Disorders Anisotropy insomnia disorder Neurology (clinical) medicine.symptom business white matter 030217 neurology & neurosurgery fractional anisotropy Diffusion MRI AcademicSubjects/MED00370 |
Zdroj: | Sleep Sleep, 43:zsaa031. American Academy of Sleep Medicine Bresser, T, Foster-Dingley, J C, Wassing, R, Leerssen, J, Ramautar, J R, Stoffers, D, Lakbila-Kamal, O, van den Heuvel, M & van Someren, E J W 2020, ' Consistent altered internal capsule white matter microstructure in insomnia disorder ', Sleep, vol. 43, no. 8 . https://doi.org/10.1093/sleep/zsaa031 Bresser, T, Foster-Dingley, J C, Wassing, R, Leerssen, J, Ramautar, J R, Stoffers, D, Lakbila-Kamal, O, Heuvel, M V D & Someren, E J W V 2020, ' Consistent altered internal capsule white matter microstructure in insomnia disorder ', Sleep, vol. 43, no. 8, pp. 1-8 . https://doi.org/10.1093/sleep/zsaa031 Sleep, 43(8), 1-8. American Academy of Sleep Medicine Sleep, 43(8). American Academy of Sleep Medicine |
ISSN: | 0161-8105 |
Popis: | Study Objectives Suggested neural correlates of insomnia disorder have been hard to replicate. Even the most consistent finding, altered white matter microstructure in the anterior limb of the internal capsule, is based on handful studies. The urge for replicable targets to understand the underlying mechanisms of insomnia made us study white matter fractional anisotropy (FA) across three samples of cases and controls. Methods 3-Tesla MRI diffusion tensor imaging data of three independent samples were combined for analysis, resulting in n = 137 participants, of whom 73 were diagnosed with insomnia disorder and 64 were matched controls without sleep complaints. Insomnia severity was measured with the Insomnia Severity Index (ISI). White matter microstructure was assessed with FA. White matter tracts were skeletonized and analyzed using tract-based spatial statistics. We performed a region-of-interest analysis using linear mixed-effect models to evaluate case–control differences in internal capsule FA as well as associations between internal capsule FA and insomnia severity. Results FA in the right limb of the anterior internal capsule was lower in insomnia disorder than in controls (β = −9.76e−3; SE = 4.17e−3, p = .034). In the entire sample, a higher ISI score was associated with a lower FA value of the right internal capsule (β = −8.05e− 4 FA/ISI point, SE = 2.60e− 4, p = .008). Ancillary whole brain voxel-wise analyses showed no significant group difference or association with insomnia severity after correction for multiple comparisons. Conclusions The internal capsule shows small but consistent insomnia-related alterations. The findings support a circuit-based approach to underlying mechanisms since this tract connects many brain areas previously implicated in insomnia. |
Databáze: | OpenAIRE |
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