Consistent altered internal capsule white matter microstructure in insomnia disorder

Autor: Jennifer R Ramautar, Rick Wassing, Eus J.W. Van Someren, Jessica C. Foster-Dingley, Tom Bresser, Diederick Stoffers, Oti Lakbila-Kamal, Jeanne Leerssen, Martijn P. van den Heuvel
Přispěvatelé: Spinoza Centre for Neuroimaging, Netherlands Institute for Neuroscience (NIN), Complex Trait Genetics, Integrative Neurophysiology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Human genetics, Psychiatry, APH - Mental Health
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Right internal capsule
medicine.medical_specialty
Internal capsule
Gastroenterology
White matter
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Internal Capsule
Physiology (medical)
Internal medicine
Sleep Initiation and Maintenance Disorders
Fractional anisotropy
mental disorders
medicine
Insomnia
Humans
internal capsule
AcademicSubjects/MED00385
medicine.diagnostic_test
business.industry
AcademicSubjects/SCI01870
Brain
Magnetic resonance imaging
diffusion tensor imaging
White matter microstructure
White Matter
030227 psychiatry
medicine.anatomical_structure
Insomnia and Psychiatric Disorders
Anisotropy
insomnia disorder
Neurology (clinical)
medicine.symptom
business
white matter
030217 neurology & neurosurgery
fractional anisotropy
Diffusion MRI
AcademicSubjects/MED00370
Zdroj: Sleep
Sleep, 43:zsaa031. American Academy of Sleep Medicine
Bresser, T, Foster-Dingley, J C, Wassing, R, Leerssen, J, Ramautar, J R, Stoffers, D, Lakbila-Kamal, O, van den Heuvel, M & van Someren, E J W 2020, ' Consistent altered internal capsule white matter microstructure in insomnia disorder ', Sleep, vol. 43, no. 8 . https://doi.org/10.1093/sleep/zsaa031
Bresser, T, Foster-Dingley, J C, Wassing, R, Leerssen, J, Ramautar, J R, Stoffers, D, Lakbila-Kamal, O, Heuvel, M V D & Someren, E J W V 2020, ' Consistent altered internal capsule white matter microstructure in insomnia disorder ', Sleep, vol. 43, no. 8, pp. 1-8 . https://doi.org/10.1093/sleep/zsaa031
Sleep, 43(8), 1-8. American Academy of Sleep Medicine
Sleep, 43(8). American Academy of Sleep Medicine
ISSN: 0161-8105
Popis: Study Objectives Suggested neural correlates of insomnia disorder have been hard to replicate. Even the most consistent finding, altered white matter microstructure in the anterior limb of the internal capsule, is based on handful studies. The urge for replicable targets to understand the underlying mechanisms of insomnia made us study white matter fractional anisotropy (FA) across three samples of cases and controls. Methods 3-Tesla MRI diffusion tensor imaging data of three independent samples were combined for analysis, resulting in n = 137 participants, of whom 73 were diagnosed with insomnia disorder and 64 were matched controls without sleep complaints. Insomnia severity was measured with the Insomnia Severity Index (ISI). White matter microstructure was assessed with FA. White matter tracts were skeletonized and analyzed using tract-based spatial statistics. We performed a region-of-interest analysis using linear mixed-effect models to evaluate case–control differences in internal capsule FA as well as associations between internal capsule FA and insomnia severity. Results FA in the right limb of the anterior internal capsule was lower in insomnia disorder than in controls (β = −9.76e−3; SE = 4.17e−3, p = .034). In the entire sample, a higher ISI score was associated with a lower FA value of the right internal capsule (β = −8.05e− 4 FA/ISI point, SE = 2.60e− 4, p = .008). Ancillary whole brain voxel-wise analyses showed no significant group difference or association with insomnia severity after correction for multiple comparisons. Conclusions The internal capsule shows small but consistent insomnia-related alterations. The findings support a circuit-based approach to underlying mechanisms since this tract connects many brain areas previously implicated in insomnia.
Databáze: OpenAIRE
Externí odkaz: