Impaired fasting pyloric compliance in gastroparesis and the therapeutic response to pyloric dilatation
| Autor: | F. Tissier, Guillaume Gourcerol, Gaëtan Prévost, Emmanuel Huet, Anne-Marie Leroi, J. Y. Touchais, Philippe Ducrotté, Chloé Melchior |
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| Přispěvatelé: | Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU), Service de physiologie digestive, urinaire, respiratoire et de l'exercice [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Hôpital Charles Nicolle [Rouen], Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Service de neurophysiologie [Rouen], Service de chirurgie digestive [CHU Rouen], Différenciation et communication neuronale et neuroendocrine (DC2N), Service d'endocrinologie, diabétologie et maladies métaboliques [Rouen] |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastroparesis medicine.medical_treatment Botulinum toxin injection Gastroenterology Pyloroplasty Internal medicine Healthy volunteers Humans Medicine Pharmacology (medical) Prospective Studies Prospective cohort study Pylorus ComputingMilieux_MISCELLANEOUS Breath test Hepatology Gastric emptying medicine.diagnostic_test business.industry [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology Fasting Middle Aged medicine.disease Dilatation 3. Good health Esophagectomy Breath Tests Gastric Emptying Quality of Life Female Caprylates business |
| Zdroj: | Alimentary Pharmacology & Therapeutics (Suppl) Alimentary Pharmacology & Therapeutics (Suppl), 2015, 41 (4), pp.360-367. ⟨10.1111/apt.13053⟩ |
| ISSN: | 0269-2813 0953-0673 1365-2036 |
| Popis: | Summary Background Pyloric pressure and compliance have never been investigated in health nor gastroparesis. Aim We hypothesised that pyloric pressure and/or compliance may be altered in gastroparesis. Methods Fasting pyloric pressure and compliance were investigated in 21 healthy volunteers (HV), 27 gastroparetic patients (GP) and 5 patients who had undergone oesophagectomy without pyloroplasty as positive controls. Under videofluoroscopic control, pyloric compliance and pressure were measured by the EndoFLIP technique. Gastric emptying half time (T1/2) using 13C–octanoic acid breath test, as well as symptoms and quality of life (GIQLI score) were also monitored. Results Mean fasting pyloric compliance was measured at 25.2 ± 2.4 mm²/mmHg in HV, and was lower both in GP (16.9 ± 2.1 mm²/mmHg; P |
| Databáze: | OpenAIRE |
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