Anaplastic Variant of Diffuse Large B-cell Lymphoma Displays Intricate Genetic Alterations and Distinct Biological Features
| Autor: | Zhe Wang, Zhou Yu, Xia Li, Yixiong Liu, Fang Liu, Shuangping Guo, Gang Chen, Hualiang Xiao, Qingguo Yan, Ying Guo, Qiongrong Chen, Linni Fan, Chubo Qi, Yingmei Wang, Mingyang Li |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty CD30 Biology Pathology and Forensic Medicine Young Adult 03 medical and health sciences 0302 clinical medicine International Prognostic Index Immunophenotyping immune system diseases hemic and lymphatic diseases medicine Humans Stage (cooking) neoplasms Aged 80 and over Middle Aged CD79B medicine.disease BCL6 Lymphoma 030104 developmental biology 030220 oncology & carcinogenesis Mutation Female Surgery Lymphoma Large B-Cell Diffuse Anatomy Diffuse large B-cell lymphoma |
| Zdroj: | American Journal of Surgical Pathology. 41:1322-1332 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/pas.0000000000000836 |
| Popis: | Anaplastic diffuse large B-cell lymphoma (A-DLBCL) is a rare morphologic variant characterized by the presence of polygonal, bizarre-shaped tumor cells. However, the clinicopathologic and genetic features of this variant are largely unknown. In this study, we investigated 35 cases of A-DLBCL with regard to their clinical, pathologic, and genetic characteristics. The age of the patients ranged from 23 to 89 years (median age, 62 y) with a male to female ratio of 23:12. Twenty-two of 26 (85%) patients had Ann Arbor stage III or IV disease, and 17/26 (65%) patients had a high-intermediate or high International Prognostic Index score. For the 24 patients treated with aggressive chemotherapy regimens, the median overall survival (OS) was 16 months, and the 2-year OS rate was 36%. Immunophenotypically, 30/35 (86%) cases had a non-germinal center B-cell immunophenotype. CD30 expression was present in 18/35 (51%) cases, and the p53 protein stain was positive in 28/35 (80%) cases. Fifteen of 35 (43%) cases expressed both BCL2 and MYC (double expressor). Twenty-nine of 32 (91%) cases tested positive for RELA, RELB, or c-Rel in the nucleus, indicating activation of the NFκB signaling pathway. Cytogenetically, 11/27 (41%) cases had concurrent MYC and BCL2 and/or BCL6 abnormalities (translocation or extra copy), including 5 cases with triple abnormalities. TP53 mutation was found in 17/30 (57%) cases, whereas the MYD88 L265P, CD79B, and CARD11 mutations were found in 7/35, 4/30, and 5/30 cases, respectively. We compared the A-DLBCL group with 50 patients with DLBCL without anaplastic features (common DLBCL). The OS of patients with A-DLBCL was significantly worse than that of patients with DLBCL without anaplastic features (P=0.004). Cases of A-DLBCL more often had a high International Prognostic Index score and a non-germinal center B-cell immunophenotype, more frequently expressed CD30 and p53, and more often had mutations of TP53 and concurrent abnormalities of MYC and BCL2 and/or BCL6 (P |
| Databáze: | OpenAIRE |
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