Chryscandin, a novel peptidyl nucleoside antibiotic. I Taxonomy, fermentation, isolation and characterization
| Autor: | Junji Hosoda, Tadaaki Komori, Yasuhisa Tsurumi, Hiroshi Imanaka, Michio Yamashita, Masanobu Kohsaka |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Pharmacology
Antifungal Agents Chemical Phenomena biology medicine.drug_class Antifungal antibiotic Antibiotics Biological activity Puromycin Aminonucleoside biology.organism_classification Acute toxicity Microbiology Chemistry Mice Biochemistry Fermentation Drug Discovery medicine Animals Puromycin Mitosporic Fungi Candida albicans Nucleoside Bacteria |
| Zdroj: | The Journal of Antibiotics. 37:1279-1283 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.37.1279 |
| Popis: | A novel antifungal antibiotic, chryscandin was found in the culture broth of a strain of fungi. The producing organism was subsequently identified as Chrysosporium pannorum. The antibiotic obtained as colorless needle crystals (C20H23N7O6, MW 457) is active against Candida albicans and Gram-positive bacteria, but it is ineffective against filamentous fungi and Gram-negative bacteria. Acute toxicity is very low in mice. |
| Databáze: | OpenAIRE |
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