Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin

Autor: Pierre Creidi, Marek Haftek, Sophie Mac-Mary, Philippe Humbert, Marie-Aude Le Bitoux, Sophie Seité, André Rougier
Přispěvatelé: Fonctions Normales et Pathologiques de la Barrière Cutanée [Hôpital Edouard Herriot - HCL], Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), La Roche Posay Pharmaceutical Laboratories, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Saas, Philippe, Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
Rok vydání: 2008
Předmět:
Pathology
MESH: Elastic Tissue
Human skin
Ascorbic Acid
Biochemistry
030207 dermatology & venereal diseases
chemistry.chemical_compound
0302 clinical medicine
Skin Physiological Phenomena
MESH: Ascorbic Acid
MESH: Double-Blind Method
MESH: Biometry
MESH: Treatment Outcome
Skin
0303 health sciences
MESH: Middle Aged
integumentary system
Dermis
Middle Aged
MESH: Administration
Cutaneous
3. Good health
Treatment Outcome
medicine.anatomical_structure
MESH: Skin Physiological Phenomena
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
Elastic fiber
Vitamin
medicine.medical_specialty
Biometry
[SDV.IMM] Life Sciences [q-bio]/Immunology
MESH: Microscopy
Electron
Dermatology
Administration
Cutaneous
03 medical and health sciences
MESH: Skin
Double-Blind Method
medicine
Humans
Molecular Biology
030304 developmental biology
MESH: Humans
business.industry
MESH: Triterpenes
Papillary dermis
MESH: Dermis
Elastic Tissue
Ascorbic acid
Elasticity
Triterpenes
Skin Aging
Microscopy
Electron
MESH: Dermatologic Agents
chemistry
Ageing
MESH: Skin Aging
MESH: Elasticity
Dermatologic Agents
Epidermis
business
MESH: Female
Zdroj: Experimental Dermatology
Experimental Dermatology, Wiley, 2008, 17 (11), pp.946-52. ⟨10.1111/j.1600-0625.2008.00732.x⟩
ISSN: 1600-0625
0906-6705
DOI: 10.1111/j.1600-0625.2008.00732.x
Popis: International audience; Skin ageing is a complex process determined by the genetic endowment of individual and environmental factors, such as sun exposure. The effects of skin ageing are mostly encountered in the superficial dermis and in the epidermis. We have previously demonstrated in vivo the beneficial effect of a topically applied formula of 5% vitamin C in the treatment of skin ageing. Another active compound, madecassoside extracted from Centella asiatica, known to induce collagen expression and/or to modulate inflammatory mediators, might thus prevent and correct some signs of ageing. A randomized double-blind study was carried out on photoaged skin of 20 female volunteers to investigate the effects of topically applied 5% vitamin C and 0.1% madecassoside on the clinical, biophysical and structural skin properties. After 6 months of treatment, we observed a significant improvement of the clinical score for deep and superficial wrinkles, suppleness, firmness, roughness and skin hydration. These results were corroborated by measurements of skin elasticity and semi-quantitative histological assessment of the elastic fibre network in the papillary dermis. Two-thirds of the subjects showed an improvement. The re-appearance of a normally structured elastic fibre network was observed. Our results revealed a functional and structural remodelling of chronically sun-damaged skin.
Databáze: OpenAIRE
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